STIM2 - stromal interaction molecule 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57620

About STIM2

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:26,860,841-27,025,381 (from NCBI)

This gene has 11 transcripts (splice variants), 271 orthologues and 1 paralogue. Ubiquitous expression in gall bladder (RPKM 9.8), lymph node (RPKM 8.6) and 25 other tissues.

Summary

This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai CA(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009]

STIM2 Products (3)

mRNA	Protein	Name
NM_001169117.2	NP_001162588.1	stromal interaction molecule 2 isoform 3 precursor
NM_001169118.2	NP_001162589.1	stromal interaction molecule 2 isoform 1 precursor
NM_020860.4	NP_065911.3	stromal interaction molecule 2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium channel regulator activity	IMP IMP: Inferred from mutant phenotype	18160041	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	18166150	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11463338	GOA
enables store-operated calcium channel activity	IDA IDA: Inferred from direct assay	16860747	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of store-operated calcium channel activity	IDA IDA: Inferred from direct assay	17905723	GOA
involved in activation of store-operated calcium channel activity	IMP IMP: Inferred from mutant phenotype	18160041	GOA
involved in intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	18160041	GOA
involved in positive regulation of calcium ion transport	IDA IDA: Inferred from direct assay	17905723	GOA
involved in positive regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	18160041	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18160041	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18160041	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STIM2 Protein Structure

SAM_2

0
200
400
600
746 a.a.

Protein Preferred Names	Protein Names
stromal interaction molecule 2

STIM2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STIM2	Q9P246	STIM1	Homo sapiens	Q13586	Anti Tag CoIP	33961781
Intra	STIM2	Q9P246	STIM1	Homo sapiens	Q13586	Anti Tag CoIP	28514442
Intra	STIM2	Q9P246	STIM1	Homo sapiens	Q13586	Anti Bait CoIP	11463338
Intra	STIM2	Q9P246	STIM1	Homo sapiens	Q13586	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

STIM2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811322	Stim2 Antibody	WB, IHC-P, ICC/IF	Human, Mouse

Related Diseases

Diseases	Alias
Immunodeficiency 10	Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 2 Combined Immunodeficiency Due To Stim1 Deficiency IMD10 Stim1 Deficiency Cid Due To Stim1 Deficiency Immune Dysfunction, With T-Cell Inactivation Due To Calcium Entry Defect 2 Immunodeficiency, Type 10
T Cell And Nk Cell Immunodeficiency
Stormorken Syndrome	Thrombocytopathy, Asplenia, And Miosis Stormorken-Sjaastad-Langslet Syndrome STRMK York Platelet Syndrome Yps Thrombocytopathy, Asplenia And Miosis Thrombocytopathy Asplenia Miosis Thrombocytopathy-Asplenia-Miosis Syndrome Miosis Disorder
Amelogenesis Imperfecta, Type Iiia	Ai3 Adhcai Amelogenesis Imperfecta Type 3 AI3A Amelogenesis Imperfecta, Type Iii Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant Amelogenesis Imperfecta Type 3a Amelogenesis Imperfecta Hypomineralization Type Amelogenesis Imperfecta Type Iii Hypocalcified Amelogenesis Imperfecta Amelogenesis Imperfecta, Type 3 Amelogenesis Imperfecta, Hypomineralization Type Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type Amelogenesis Imperfecta 3a Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant
Myopathy, Tubular Aggregate, 1	Tubular Aggregate Myopathy Tam Myopathy With Tubular Aggregates TAM1 Myopathy, Tubular Aggregate Tubular Aggregate Myopathy 1
Anhidrosis	Hypohidrosis Absence Of Sweating Adiaphoresis Impaired Sweating Oligohidrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13914	STIM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22834	Stim2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29349	Stim2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	STIM2	RGD	RGD:1304641
Bos taurus	STIM2	VGNC	VGNC:53776
Macaca mulatta	STIM2	VGNC	VGNC:77965
Canis familiaris	STIM2	VGNC	VGNC:46902
Felis catus	STIM2	VGNC	VGNC:65773
Mus musculus	STIM2	MGD	MGI:2151156
Others	STIM2	NCBI