2. Gene
  3. HCN3 - hyperpolarization activated cyclic nucleotide gated potassium channel 3 Gene

HCN3 - hyperpolarization activated cyclic nucleotide gated potassium channel 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 57657 | Gene type: protein coding

About HCN3

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,277,463-155,289,848 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 343 orthologues and 17 paralogues. Ubiquitous expression in liver (RPKM 3.6), duodenum (RPKM 2.6) and 25 other tissues.

Summary

This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

HCN3 Products(1)

mRNA Protein Name
NM_020897.3 NP_065948.1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

HCN3 Protein Structure

Ion_trans_N

Ion_trans_N: Ion transport protein N-terminal (49 - 123)

Ion_trans

Ion_trans: Ion transport protein (129 - 344)

cNMP_binding

cNMP_binding: Cyclic nucleotide-binding domain (447 - 530)

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  • 774 a.a.
Protein Preferred Names Protein Names

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

Related Diseases

Diseases Alias
Bladder Neck Obstruction

Obstruction Of Bladder Neck Or Vesicourethral Orifice

Urinary Bladder Neck Obstruction

Bladder Outlet Obstruction

Vesicourethral Orifice Obstruction

Bno - [Bladder Neck Obstruction]

Bladder Obstruction Nos

Acquired Bladder Neck Obstruction

Acquired Obstruction Of Bladder Neck Or Vesicourethral Orifice

Bladder Neck Strangulation

Bladder Neck Stricture

Bladder Outflow Obstruction

Contracture Of Bladder Neck Or Sphincter

Contracture Of Bladder Neck

Obstructed Vesicourethral Orifice

Strangulation Of Vesicourethral Orifice

Stricture Of Vesicourethral Orifice

Urinary Prostatic Valve Obstruction

Vesical Obstruction
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13422 Zatebradine hydrochloride Antagonist 99.06% Unkown
HY-13422A Zatebradine Antagonist 99.59% Unkown
HY-RS06048 HCN3 Human Pre-designed siRNA Set A / Unkown
HY-160505 RO-275 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HCN3 VGNC VGNC:41621
Bos taurus HCN3 VGNC VGNC:29778
Mus musculus HCN3 MGD MGI:1298211
Macaca mulatta HCN3 VGNC VGNC:106379
Rattus norvegicus HCN3 RGD RGD:620691