HCN3 - hyperpolarization activated cyclic nucleotide gated potassium channel 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57657

About HCN3

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,277,463-155,289,848 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 343 orthologues and 17 paralogues. Ubiquitous expression in liver (RPKM 3.6), duodenum (RPKM 2.6) and 25 other tissues.

Summary

This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

HCN3 Products (1)

mRNA Protein Name
NM_020897.3 NP_065948.1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26966193 GOA
enables voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
16043489 GOA
enables voltage-gated potassium channel activity IMP
IMP: Inferred from mutant phenotype
22748890 GOA
enables voltage-gated sodium channel activity IDA
IDA: Inferred from direct assay
16043489 GOA
enables voltage-gated sodium channel activity IMP
IMP: Inferred from mutant phenotype
22748890 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in cellular response to cAMP IDA
IDA: Inferred from direct assay
22748890 GOA
involved in potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
16043489 GOA
involved in potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
22748890 GOA
involved in regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
22748890 GOA
involved in sodium ion transmembrane transport IDA
IDA: Inferred from direct assay
16043489 GOA
involved in sodium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
22748890 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
22748890 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HCN3 Protein Structure

Ion_trans_N

Ion_trans_N: Ion transport protein N-terminal (49 - 123)

Ion_trans

Ion_trans: Ion transport protein (129 - 344)

cNMP_binding

cNMP_binding: Cyclic nucleotide-binding domain (447 - 530)

  • 0
  • 200
  • 400
  • 600
  • 774 a.a.
Protein Preferred Names Protein Names

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

Related Diseases

Diseases Alias
Bladder Neck Obstruction

  • Obstruction Of Bladder Neck Or Vesicourethral Orifice

  • Urinary Bladder Neck Obstruction

  • Bladder Outlet Obstruction

  • Vesicourethral Orifice Obstruction

  • Bno - [Bladder Neck Obstruction]

  • Bladder Obstruction Nos

  • Acquired Bladder Neck Obstruction

  • Acquired Obstruction Of Bladder Neck Or Vesicourethral Orifice

  • Bladder Neck Strangulation

  • Bladder Neck Stricture

  • Bladder Outflow Obstruction

  • Contracture Of Bladder Neck Or Sphincter

  • Contracture Of Bladder Neck

  • Obstructed Vesicourethral Orifice

  • Strangulation Of Vesicourethral Orifice

  • Stricture Of Vesicourethral Orifice

  • Urinary Prostatic Valve Obstruction

  • Vesical Obstruction
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-18940 Cilobradine / Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160505 RO-275 Inhibitor 99.95% Unkown
HY-13422A Zatebradine Antagonist 99.27% Unkown
HY-13422 Zatebradine hydrochloride Antagonist 99.87% Unkown
HY-RS06048 HCN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19140 Hcn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20286 Hcn4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25631 Hcn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HCN3 VGNC VGNC:41621
Bos taurus HCN3 VGNC VGNC:29778
Mus musculus HCN3 MGD MGI:1298211
Macaca mulatta HCN3 VGNC VGNC:106379
Rattus norvegicus HCN3 RGD RGD:620691
Others HCN3 NCBI