QSOX1 - quiescin sulfhydryl oxidase 1 Gene

Also Known as Q6; QSCN6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5768

About QSOX1

Cytogenetic location: 1q25.2 Genomic coordinates (GRCh38): 1:180,154,869-180,204,030 (from NCBI)

This gene has 4 transcripts (splice variants), 208 orthologues and 1 paralogue. Broad expression in gall bladder (RPKM 86.5), stomach (RPKM 79.3) and 25 other tissues.

Summary

This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

QSOX1 Products (2)

mRNA Protein Name
NM_001004128.3 NP_001004128.1 sulfhydryl oxidase 1 isoform b precursor
NM_002826.5 NP_002817.2 sulfhydryl oxidase 1 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables FAD binding IDA
IDA: Inferred from direct assay
20211621 GOA
enables flavin-dependent sulfhydryl oxidase activity IDA
IDA: Inferred from direct assay
17331072 GOA
enables protein disulfide isomerase activity IDA
IDA: Inferred from direct assay
17331072 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in extracellular matrix assembly IMP
IMP: Inferred from mutant phenotype
23867277 GOA
involved in negative regulation of macroautophagy IMP
IMP: Inferred from mutant phenotype
24475161 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
17331072 GOA
located in extracellular exosome IDA
IDA: Inferred from direct assay
21082674 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
10708601 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

QSOX1 Protein Structure

Thioredoxin

Thioredoxin: Thioredoxin (50 - 129)

Evr1_Alr

Evr1_Alr: Erv1 / Alr family (405 - 504)

  • 0
  • 200
  • 400
  • 600
  • 747 a.a.
Protein Preferred Names Protein Names

sulfhydryl oxidase 1

  • quiescin Q6 sulfhydryl oxidase 1

QSOX1 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P81376 QSOX1 Antibody (YA1121) IHC-P Human
HY-P81376A QSOX1 Antibody (YA1121)(PBS only) IHC-P Human

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-13750 Ebselen Inhibitor 99.91% Yes

Pre-clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-165245 SBI-183 Inhibitor 99.8% Unkown
HY-171148 F1-RIBOTAC / Unkown
HY-168460 RNA recruiter 2 / Unkown
HY-RS11509 QSOX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17843 Qsox1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24311 Qsox1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus QSOX1 VGNC VGNC:33605
Rattus norvegicus QSOX1 RGD RGD:68957
Canis familiaris QSOX1 VGNC VGNC:45238
Felis catus QSOX1 VGNC VGNC:69200
Macaca mulatta QSOX1 VGNC VGNC:106478
Mus musculus QSOX1 MGD MGI:1330818
Others QSOX1 NCBI