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Tbx21 - T-box 21 Gene

Also Known as TBT1; Tbet; Tblym

Species: Mus musculus

Gene Type: protein coding

Gene ID: 57765

Summary

Enables DNA binding activity. Involved in several processes, including negative regulation of T-helper 17 cell lineage commitment; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of gene expression. Acts upstream of or within T cell differentiation; cellular response to organic substance; and positive regulation of isotype switching to IgG isotypes. Located in neuronal cell body and nucleus. Is expressed in several structures, including central nervous system; colon; genitourinary system; sensory organ; and thymus. Used to study asthma. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human TBX21 (T-box transcription factor 21). [provided by Alliance of Genome Resources, Apr 2022]

Tbx21 Products (1)

mRNA	Protein	Name
NM_019507.2	NP_062380.2	T-box transcription factor TBX21

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IMP IMP: Inferred from mutant phenotype	23616576	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10761931	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15662016	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within T cell differentiation	IMP IMP: Inferred from mutant phenotype	20399120	MGI
involved in T-helper 1 cell lineage commitment	IDA IDA: Inferred from direct assay	10761931	MGI
involved in lymphocyte migration	IMP IMP: Inferred from mutant phenotype	19805038	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15662016	MGI
involved in negative regulation of T-helper 17 cell differentiation	IDA IDA: Inferred from direct assay	21151104	MGI
involved in negative regulation of T-helper 17 cell lineage commitment	IMP IMP: Inferred from mutant phenotype	21151104	MGI
involved in negative regulation of T-helper 2 cell cytokine production	IDA IDA: Inferred from direct assay	10761931	MGI
involved in negative regulation of T-helper 2 cell cytokine production	IMP IMP: Inferred from mutant phenotype	23616576	MGI
involved in negative regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	23616576	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21690296	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15662016	MGI
involved in positive regulation of T-helper 1 cell cytokine production	IDA IDA: Inferred from direct assay	10761931	MGI
acts upstream of or within positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	22851706	MGI
acts upstream of or within positive regulation of isotype switching to IgG isotypes	IMP IMP: Inferred from mutant phenotype	12882831	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10761931	MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	23616576	MGI
involved in regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	21690296	MGI
acts upstream of or within regulation of immune response	IMP IMP: Inferred from mutant phenotype	12882831	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in neuronal cell body	IDA IDA: Inferred from direct assay	15677725	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15662016	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
T-box transcription factor TBX21	T-box protein 21 T-cell-specific T-box transcription factor T-bet transcription factor TBLYM

Tbx21 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Tbx21	Q9JKD8	Runx1	Mus musculus	Q03347	Anti Bait CoIP	21151104
Intra	Tbx21	Q9JKD8	Bcl6	Mus musculus	P41183	Anti Bait CoIP	22406686

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS21062	Tbx21 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14277	TBX21 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27579	Tbx21 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tbx21	NCBI	NCBI:30009