Casp9 - caspase 9 Gene

Also Known as Mch6; Apaf3; Casp9_v1; Ice-Lap6; Casp-9-CTD

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 58918

About Casp9

Primary_assembly 5: 154,109,046-154,126,626 forward strand.mRatBN7.2:CM026978.1

This gene has 3 transcripts (splice variants), 204 orthologues, 12 paralogues and is associated with 64 phenotypes. Biased expression in Spleen (RPKM 7.4), Adrenal (RPKM 66.9) and 9 other tissues.

Summary

Enables cysteine-type peptidase activity. Involved in several processes, including glial cell apoptotic process; response to estradiol; and response to ischemia. Located in cytosol; mitochondrion; and nucleus. Used to study pre-malignant neoplasm. Biomarker of several diseases, including cerebrovascular disease (multiple); heart disease (multiple); kidney disease (multiple); neurodegenerative disease (multiple); and post-traumatic stress disorder. Human ortholog(s) of this gene implicated in several diseases, including Parkinson's disease; colorectal cancer; lung non-small cell carcinoma; pancreatic cancer; and type 2 diabetes mellitus. Orthologous to human CASP9 (Caspase 9). [provided by Alliance of Genome Resources, Apr 2022]

Casp9 Products (1)

mRNA Protein Name
NM_031632.2 NP_113820.1 caspase-9

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cysteine-type peptidase activity IDA
IDA: Inferred from direct assay
16336964 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18485100 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16987298 RGD
involved in glial cell apoptotic process IEP
IEP: Inferred from expression pattern
18931364 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
27665619 RGD
involved in leukocyte apoptotic process IEP
IEP: Inferred from expression pattern
26861981 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17869439 RGD
involved in protein processing IDA
IDA: Inferred from direct assay
18316105 RGD
involved in response to cobalt ion IEP
IEP: Inferred from expression pattern
18598848 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
18598848 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
24089674 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
11934844 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18289516 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
17297389 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp9 Protein Structure

CARD_CASP9

CARD_CASP9: cd08326 (18 - 89)

CASc

CASc: cd00032 (189 - 451)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 454 a.a.
Protein Preferred Names Protein Names

caspase-9

  • 25 kDa caspase-9 dominant negative protein

  • Ice-like apoptotic protease 6

  • apoptotic protease Mch-6

  • apoptotic protease activating factor 3

  • caspase 9, apoptosis-related cysteine peptidase

  • caspase-9 dominant negative form

  • caspase-9-carboxyl-terminal divergent

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp9 NCBI NCBI:842