2. Gene
  3. Casp9 - caspase 9 Gene

Casp9 - caspase 9 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Mch6; Apaf3; Casp9_v1; Ice-Lap6; Casp-9-CTD

Gene ID: 58918 | Gene type: protein coding

About Casp9

Primary_assembly 5: 154,109,046-154,126,626 forward strand.mRatBN7.2:CM026978.1

This gene has 3 transcripts (splice variants), 204 orthologues, 12 paralogues and is associated with 64 phenotypes. Biased expression in Spleen (RPKM 7.4), Adrenal (RPKM 66.9) and 9 other tissues.

Summary

Enables cysteine-type peptidase activity. Involved in several processes, including glial cell apoptotic process; response to estradiol; and response to ischemia. Located in cytosol; mitochondrion; and nucleus. Used to study pre-malignant neoplasm. Biomarker of several diseases, including cerebrovascular disease (multiple); heart disease (multiple); kidney disease (multiple); neurodegenerative disease (multiple); and post-traumatic stress disorder. Human ortholog(s) of this gene implicated in several diseases, including Parkinson's disease; colorectal cancer; lung non-small cell carcinoma; pancreatic cancer; and type 2 diabetes mellitus. Orthologous to human CASP9 (Caspase 9). [provided by Alliance of Genome Resources, Apr 2022]

Casp9 Products(1)

mRNA Protein Name
NM_031632.2 NP_113820.1 caspase-9

Casp9 Protein Structure

CARD_CASP9

CARD_CASP9: cd08326 (18 - 89)

CASc

CASc: cd00032 (189 - 451)

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  • 454 a.a.
Protein Preferred Names Protein Names

caspase-9

25 kDa caspase-9 dominant negative protein

Ice-like apoptotic protease 6

apoptotic protease Mch-6

apoptotic protease activating factor 3

caspase 9, apoptosis-related cysteine peptidase

caspase-9 dominant negative form

caspase-9-carboxyl-terminal divergent

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01969 CASP9 Human Pre-designed siRNA Set A / Unkown
HY-RS01970 Casp9 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01971 Casp9 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp9 NCBI NCBI:842