Dynll1 - dynein light chain LC8-type 1 Gene

Also Known as Pin; Dlc8; 8kDLC; Dnclc1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 58945

Summary

Enables several functions, including identical protein binding activity; nitric-oxide synthase regulator activity; and scaffold protein binding activity. Involved in positive regulation of Insulin secretion involved in cellular response to glucose stimulus and spermatid development. Acts upstream of or within negative regulation of nitric oxide biosynthetic process. Located in axon cytoplasm; nucleus; and secretory granule. Part of cytoplasmic dynein complex. Colocalizes with mitochondrion. Used to study hypertension and impotence. Biomarker of cardiac arrest; congestive heart failure; and middle cerebral artery infarction. Orthologous to human DYNLL1 (dynein light chain LC8-type 1). [provided by Alliance of Genome Resources, Apr 2022]

Dynll1 Products (1)

mRNA Protein Name
NM_053319.4 NP_445771.1 dynein light chain 1, cytoplasmic

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
14760703 RGD
enables enzyme inhibitor activity IDA
IDA: Inferred from direct assay
8864115 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
12904292 RGD
enables nitric-oxide synthase inhibitor activity IDA
IDA: Inferred from direct assay
8864115 RGD
enables nitric-oxide synthase regulator activity IDA
IDA: Inferred from direct assay
8864115 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15384421 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
17965411 RGD
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
12097491 RGD
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
8864115 RGD
involved in negative regulation of nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
8864115 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
IDA: Inferred from direct assay
17130471 RGD
involved in spermatid development IEP
IEP: Inferred from expression pattern
15983119 RGD
Cellular Component GO Annotation Evidence References Source
located in axon cytoplasm IDA
IDA: Inferred from direct assay
19641106 RGD
part of cytoplasmic dynein complex IDA
IDA: Inferred from direct assay
8702622 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
17130471 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dynein light chain 1, cytoplasmic

  • 8 kDa dynein light chain

  • 8kD LC

  • dynein LC8

  • dynein, cytoplasmic, light chain 1

  • protein inhibitor of neuronal nitric oxide synthase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04088 DYNLL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19253 Dynll1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25742 Dynll1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dynll1 NCBI NCBI:8655