ROBO1 - Robo1 roundabout guidance receptor 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 58946

Summary

Enables axon guidance receptor activity. Involved in axon midline choice point recognition; regulation of dendrite morphogenesis; and spinal cord development. Located in axon and neuronal cell body. Biomarker of lung non-small cell carcinoma. Orthologous to human ROBO1 (roundabout guidance receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

ROBO1 Products (1)

mRNA Protein Name
NM_022188.2 NP_071524.2 roundabout homolog 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables axon guidance receptor activity IDA
IDA: Inferred from direct assay
9458045 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10102268 RGD
Biological Process GO Annotation Evidence References Source
involved in axon guidance IDA
IDA: Inferred from direct assay
9458045 RGD
involved in axon midline choice point recognition IEP
IEP: Inferred from expression pattern
18986510 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
23994690 RGD
involved in negative regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
27893610 RGD
involved in neuron projection extension IMP
IMP: Inferred from mutant phenotype
26738857 RGD
involved in oligodendrocyte development IEP
IEP: Inferred from expression pattern
22433866 RGD
involved in regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
11779479 RGD
involved in spinal cord development IEP
IEP: Inferred from expression pattern
10102268 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
18986510 RGD
located in dendrite IDA
IDA: Inferred from direct assay
26738857 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
18986510 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

roundabout homolog 1

  • roundabout, axon guidance receptor, homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175200 DEL-S1 Ligand 98.50% Unkown
HY-RS12110 ROBO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20096 Robo1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26599 Robo1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ROBO1 NCBI NCBI:6091