Huwe1 - HECT, UBA and WWE domain containing 1 Gene

Also Known as Mule; Ib772; LASU1; Ureb1; Gm1718; Arf-bp1; 5430439H10Rik; C430014N20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 59026

Summary

Predicted to enable DNA binding activity and ubiquitin protein Ligase activity. Involved in circadian regulation of gene expression and positive regulation of protein ubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in Golgi membrane and nucleus. Is expressed in several structures, including extraembryonic component. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein Ligase 1). [provided by Alliance of Genome Resources, Apr 2022]

Huwe1 Products (1)

mRNA Protein Name
NM_021523.5 NP_067498.4 E3 ubiquitin-protein ligase HUWE1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20534529 MGI
involved in positive regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
20534529 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase HUWE1

  • E3Histone

  • HECT, UBA and WWE domain-containing protein 1

  • HECT-type E3 ubiquitin transferase HUWE1

  • Mcl-1 ubiquitin ligase

  • URE-B1

  • URE-binding protein 1

  • upstream regulatory element binding protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120929 BI8622 Inhibitor 98.16% Unkown
HY-120204 BI8626 Inhibitor 98.49% Unkown
HY-RS06493 HUWE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18391 Huwe1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24872 Huwe1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Huwe1 NCBI NCBI:10075