Grk4 - G protein-coupled receptor kinase 4 Gene

Also Known as Gprk2l

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 59077

Summary

Enables rhodopsin kinase activity. Involved in G protein-coupled receptor internalization and protein phosphorylation. Located in cytosol; dendrite; and neuronal cell body. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human GRK4 (G protein-coupled receptor kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Grk4 Products (1)

mRNA Protein Name
NM_022928.1 NP_075217.1 G protein-coupled receptor kinase 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables rhodopsin kinase activity IDA
IDA: Inferred from direct assay
9607785 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor internalization IMP
IMP: Inferred from mutant phenotype
12519791 RGD
involved in desensitization of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15166006 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9607785 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
11099476 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
11099476 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

G protein-coupled receptor kinase 4

  • G protein-coupled receptor kinase 2, groucho gene related

  • g protein-coupled receptor kinase GRK4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-142812 GRK6-IN-1 99.61% Unkown
HY-RS05815 GRK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20282 Grk4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26790 Grk4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grk4 NCBI NCBI:2868