GRK4 - G protein-coupled receptor kinase 4 Gene

Also Known as IT11; GPRK4; GRK4a; GPRK2L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2868

About GRK4

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,963,571-3,040,760 (from NCBI)

This gene has 10 transcripts (splice variants), 187 orthologues and 7 paralogues. Biased expression in testis (RPKM 14.6) and brain (RPKM 0.7).

Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GRK4 Products (5)

mRNA Protein Name
NM_001004056.2 NP_001004056.1 G protein-coupled receptor kinase 4 isoform beta
NM_001004057.2 NP_001004057.1 G protein-coupled receptor kinase 4 isoform gamma
NM_001350173.2 NP_001337102.1 G protein-coupled receptor kinase 4 isoform 5
NM_005307.3 NP_005298.2 G protein-coupled receptor kinase 4 isoform delta
NM_182982.3 NP_892027.2 G protein-coupled receptor kinase 4 isoform alpha

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32707033 GOA
Biological Process GO Annotation Evidence References Source
involved in receptor internalization IDA
IDA: Inferred from direct assay
20074556 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRK4 Protein Structure

RGS

RGS: Regulator of G protein signaling domain (53 - 171)

Pkinase

Pkinase: Protein kinase domain (189 - 447)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 578 a.a.
Protein Preferred Names Protein Names

G protein-coupled receptor kinase 4

  • G protein-coupled receptor kinase 2-like

GRK4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GRK4 P32298 GRK6 Homo sapiens P43250
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Hermansky-Pudlak Syndrome 3

  • HPS3

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

  • Delta Storage Pool Disease

  • Hermansky-Pudlak Syndrome, Type 3

  • Platelet Storage Pool Deficiency

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-142812 GRK6-IN-1 99.61% Unkown
HY-RS05815 GRK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20282 Grk4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26790 Grk4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GRK4 MGD MGI:95801
Rattus norvegicus GRK4 RGD RGD:61858
Macaca mulatta GRK4 VGNC VGNC:73266
Canis familiaris GRK4 VGNC VGNC:41504
Bos taurus GRK4 VGNC VGNC:29655
Felis catus GRK4 VGNC VGNC:78506
Others GRK4 NCBI