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HIVEP3 - HIVEP zinc finger 3 Gene

Also Known as KRC; KBP1; SHN3; ZAS3; KBP-1; ZNF40C; Schnurri-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 59269

About HIVEP3

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:41,506,365-42,035,934 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and 14 paralogues. Ubiquitous expression in skin (RPKM 2.3), brain (RPKM 1.1) and 24 other tissues.

Summary

This gene encodes a member of the human immunodeficiency virus type 1 enhancer-binding protein family. Members of this protein family contain multiple zinc finger and acid-rich (ZAS) domains and serine-threonine rich regions. This protein acts as a transcription factor and is able to regulate nuclear factor kappaB-mediated transcription by binding the kappaB motif in target genes. This protein also binds the recombination signal sequence that flanks the V, D, and J regions of immunoglobulin and T-cell receptors. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Sep 2011]

HIVEP3 Products (2)

mRNA	Protein	Name
NM_001127714.3	NP_001121186.1	transcription factor HIVEP3 isoform b
NM_024503.5	NP_078779.2	transcription factor HIVEP3 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	34341191	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15790681	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HIVEP3 Protein Structure

zf-H2C2_2

0
400
800
1200
1600
2000
2406 a.a.

Protein Preferred Names	Protein Names
transcription factor HIVEP3	ZAS family, member 3

HIVEP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HIVEP3	Q5T1R4	YWHAG	Homo sapiens	P61981	ITC	34341191
Intra	HIVEP3	Q5T1R4	YWHAG	Homo sapiens	P61981	FPS	34341191
Intra	HIVEP3	Q5T1R4	SFN	Homo sapiens	P31947	FPS	34341191
Intra	HIVEP3	Q5T1R4	SFN	Homo sapiens	P31947	ITC	34341191
Intra	HIVEP3	Q5T1R4	SFN	Homo sapiens	P31947	X-Ray Diffraction	34341191

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Laurence-Moon Syndrome	LNMS Laurence-Moon-Biedl Syndrome
Meckel Syndrome, Type 1	Meckel-Gruber Syndrome Meckel Syndrome Dysencephalia Splanchnocystica Meckel Syndrome 1 MKS1 Mks Gruber Syndrome Meckel-Gruber Syndrome, Type 1 Mes Dysencephalia Splachnocystica Meckel Gruber Syndrome Meckel Syndrome Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06189	HIVEP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HIVEP3	VGNC	VGNC:96556
Felis catus	HIVEP3	VGNC	VGNC:96549
Rattus norvegicus	HIVEP3	RGD	RGD:1311252
Canis familiaris	HIVEP3	VGNC	VGNC:81689
Bos taurus	HIVEP3	VGNC	VGNC:96544
Mus musculus	HIVEP3	MGD	MGI:106589
Others	HIVEP3	NCBI