Mapk12 - mitogen-activated protein kinase 12 Gene

Also Known as Sapk3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60352

About Mapk12

Primary_assembly 7: 120,206,271-120,216,664 reverse strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 288 orthologues, 21 paralogues and is associated with 4 phenotypes. Biased expression in Muscle (RPKM 389.8), Lung (RPKM 98.4) and 6 other tissues.

Summary

Enables ATP binding activity and MAP kinase activity. Involved in negative regulation of cell cycle and protein phosphorylation. Located in cytoplasm. Orthologous to human MAPK12 (mitogen-activated protein kinase 12). [provided by Alliance of Genome Resources, Apr 2022]

Mapk12 Products (1)

mRNA Protein Name
NM_021746.2 NP_068514.1 mitogen-activated protein kinase 12

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
16879317 RGD
enables MAP kinase activity IDA
IDA: Inferred from direct assay
16879317 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10212242 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10438538 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell cycle IDA
IDA: Inferred from direct assay
10438538 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
16879317 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11991731 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk12 Protein Structure

STKc_p38gamma

STKc_p38gamma: cd07880 (10 - 352)

  • 0
  • 100
  • 200
  • 300
  • 367 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 12

  • ERK-6

  • MAP kinase 12

  • MAP kinase p38 gamma

  • MAPK 12

  • SAP kinase-3

  • extracellular signal-regulated kinase 6

  • mitogen-activated protein kinase p38 gamma

  • stress-activated protein kinase 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2441 Methylophiopogonone A Inhibitor 99.94% Unkown
HY-186241 NuP-3 Inhibitor / Unkown
HY-RS08101 MAPK12 Human Pre-designed siRNA Set A / Unkown
HY-RS08102 Mapk12 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08103 Mapk12 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk12 NCBI NCBI:6300