MAPK12 - mitogen-activated protein kinase 12 Gene

Also Known as ERK3; ERK6; ERK-6; SAPK3; PRKM12; SAPK-3; MAPK 12; P38GAMMA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6300

About MAPK12

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,252,901-50,261,683 (from NCBI)

This gene has 11 transcripts (splice variants), 288 orthologues and 19 paralogues. Ubiquitous expression in brain (RPKM 6.0), prostate (RPKM 5.7) and 24 other tissues.

Summary

Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]

MAPK12 Products (2)

mRNA Protein Name
NM_002969.6 NP_002960.2 mitogen-activated protein kinase 12 isoform 1
NM_001303252.3 NP_001290181.1 mitogen-activated protein kinase 12 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables magnesium ion binding IDA
IDA: Inferred from direct assay
10508788 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12761180 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
8633070 GOA
Biological Process GO Annotation Evidence References Source
involved in myoblast differentiation IDA
IDA: Inferred from direct assay
8633070 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
15850461 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPK12 Protein Structure

Pkinase

Pkinase: Protein kinase domain (27 - 311)

  • 0
  • 100
  • 200
  • 300
  • 367 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 12

  • MAP kinase 12

  • MAP kinase p38 gamma

  • extracellular signal-regulated kinase 6

  • mitogen-activated protein kinase 3

  • mitogen-activated protein kinase p38 gamma

  • stress-activated protein kinase 3

MAPK12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAPK12 P53778 DLG1 Homo sapiens Q12959
PLA
25241761
Intra
MAPK12 P53778 PKN1 Homo sapiens Q16512
Anti Tag CoIP
12761180
Intra
MAPK12 P53778 SIAH1 Homo sapiens Q8IUQ4
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAPK12 Proteins

Cat. No. Product Name Accession Purity
HY-P76532 p38 gamma/MAPK12 Protein, Human (sf9) P53778-1 (N-G&P, M1-L367) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76533 p38 gamma/MAPK12 Protein, Human (sf9, His-GST) P53778-1 (M1-L367) ≥ 95%, as determined by reducing SDS-PAGE.

MAPK12 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87165 p38 gamma/MAPK12 Antibody (YA6858) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Male Breast Cancer

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Spinocerebellar Ataxia, X-Linked 5

  • SCAX5

  • X-Linked Spinocerebellar Ataxia 5

  • X-Linked Non Progressive Cerebellar Ataxia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2441 Methylophiopogonone A Inhibitor 99.84% Unkown
HY-186241 NuP-3 Inhibitor / Unkown
HY-RS08101 MAPK12 Human Pre-designed siRNA Set A / Unkown
HY-RS08102 Mapk12 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08103 Mapk12 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MAPK12 RGD RGD:70975
Macaca mulatta MAPK12 VGNC VGNC:74643
Mus musculus MAPK12 MGD MGI:1353438
Bos taurus MAPK12 VGNC VGNC:31215
Canis familiaris MAPK12 VGNC VGNC:42993
Others MAPK12 NCBI