Lin7b - lin-7 homolog B, crumbs cell polarity complex component Gene

Also Known as MALS2; Veli2; Veli1a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60377

Summary

Enables PDZ domain binding activity. Predicted to be involved in maintenance of epithelial cell apical/basal polarity; neurotransmitter secretion; and protein localization to basolateral plasma membrane. Located in cell-cell junction and synapse. Orthologous to human LIN7B (lin-7 homolog B, crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Apr 2022]

Lin7b Products (1)

mRNA Protein Name
NM_021758.2 NP_068526.1 protein lin-7 homolog B

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IDA
IDA: Inferred from direct assay
14596909 RGD
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
14596909 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
14596909 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
17084383 RGD
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
10362251 RGD
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
24753440 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein lin-7 homolog B

  • MALS-2

  • lin 7 homolog b

  • lin-7-A

  • lin-7B

  • mammalian lin-seven protein 2

  • veli-2 protein

  • vertebrate homolog of C. elegans Lin-7 type 2

  • vertebrate lin-7 homolog 2

Lin7b Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Lin7b Q9Z252 Baiap2 Rattus norvegicus Q6GMN2
Y2H
14596909
Intra
Lin7b Q9Z252 Baiap2 Rattus norvegicus Q6GMN2
Anti Bait CoIP
14596909
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07677 LIN7B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lin7b NCBI NCBI:64130