BAIAP2 - Baiap2 BAR/IMD domain containing adaptor protein 2 Gene

Also Known as Irsp53

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117542

Summary

Enables PDZ domain binding activity; scaffold protein binding activity; and transcription coregulator binding activity. Involved in several processes, including cellular response to L-glutamate; nervous system development; and regulation of synapse organization. Located in several cellular components, including dendrite; lamellipodium; and neuron projection branch point. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density, intracellular component; and presynaptic cytosol. Colocalizes with postsynaptic density. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and autism spectrum disorder. Orthologous to human BAIAP2 (BAR/IMD domain containing adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]

BAIAP2 Products (1)

mRNA Protein Name
NM_057196.1 NP_476544.1 brain-specific angiogenesis inhibitor 1-associated protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IDA
IDA: Inferred from direct assay
14596909 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
14596909 RGD
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
12421375 RGD
enables transcription coregulator binding IPI
IPI: Inferred from physical interaction
10332026 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to L-glutamate IEP
IEP: Inferred from expression pattern
15758177 RGD
involved in cellular response to epidermal growth factor stimulus IEP
IEP: Inferred from expression pattern
17855387 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
25586189 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
15673667 RGD
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
15758177 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
25586189 RGD
involved in protein localization to synapse IMP
IMP: Inferred from mutant phenotype
15758177 RGD
involved in regulation of modification of postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
15673667 RGD
involved in regulation of modification of postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
15673667 RGD
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
15673667 RGD
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
15673667 RGD
Cellular Component GO Annotation Evidence References Source
located in dendritic shaft IDA
IDA: Inferred from direct assay
24639075 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
15758177 RGD
located in dendritic spine cytoplasm IDA
IDA: Inferred from direct assay
15673667 RGD
located in excitatory synapse IDA
IDA: Inferred from direct assay
24639075 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15673667 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
15673667 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
18480067 RGD
located in microtubule IDA
IDA: Inferred from direct assay
24639075 RGD
located in neuron projection branch point IDA
IDA: Inferred from direct assay
25586189 RGD
located in neuron projection terminus IDA
IDA: Inferred from direct assay
25586189 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15758177 RGD
located in postsynapse IDA
IDA: Inferred from direct assay
15673667 RGD
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
15673667 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
25293574 RGD
is active in postsynaptic density IMP
IMP: Inferred from mutant phenotype
25293574 RGD
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
15673667 RGD
located in presynapse IDA
IDA: Inferred from direct assay
15673667 RGD
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
15673667 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
17120053 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
15673667 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

brain-specific angiogenesis inhibitor 1-associated protein 2

  • BAI-associated protein 2

  • BAI1-associated protein 2

  • brain-specific angiogenesis inhibitor 1-associated protein 2-like

  • insulin receptor substrate 53

  • insulin receptor substrate p53

  • insulin receptor substrate protein of 53 kDa

  • insulin receptor tyrosine

BAIAP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Baiap2 Q6GMN2 Lin7b Rattus norvegicus Q9Z252
Pull Down
14596909
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01353 BAIAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01354 BAIAP2L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01355 BAIAP2L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21826 Baiap2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28343 Baiap2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens BAIAP2 NCBI NCBI:10458