Tsc1 - TSC complex subunit 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60445

Summary

Enables GTPase activating protein binding activity and protein N-terminus binding activity. Involved in several processes, including cellular response to oxygen-glucose deprivation; negative regulation of GTPase activity; and regulation of macroautophagy. Located in several cellular components, including cytosol; growth cone; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study obesity. Human ortholog(s) of this gene implicated in intellectual disability; lymphangioleiomyomatosis; tuberous sclerosis; and tuberous sclerosis 1. Orthologous to human TSC1 (TSC complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Tsc1 Products (1)

mRNA Protein Name
NM_021854.2 NP_068626.1 hamartin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17355907 RGD
Biological Process GO Annotation Evidence References Source
involved in adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
23435171 RGD
involved in cellular response to decreased oxygen levels IMP
IMP: Inferred from mutant phenotype
23435171 RGD
involved in negative regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
15611338 RGD
involved in negative regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
23435171 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17376623 RGD
involved in negative regulation of cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
23435171 RGD
involved in negative regulation of macroautophagy IMP
IMP: Inferred from mutant phenotype
23435171 RGD
involved in negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
17376623 RGD
involved in positive regulation of macroautophagy IDA
IDA: Inferred from direct assay
23435171 RGD
involved in positive regulation of stress fiber assembly IMP
IMP: Inferred from mutant phenotype
15611338 RGD
involved in regulation of focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
15611338 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
31787541 RGD
involved in response to peptide IEP
IEP: Inferred from expression pattern
31787541 RGD
Cellular Component GO Annotation Evidence References Source
located in cell projection IDA
IDA: Inferred from direct assay
17376623 RGD
located in growth cone IDA
IDA: Inferred from direct assay
12226091 RGD
located in nucleus IDA
IDA: Inferred from direct assay
23435171 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
23435171 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hamartin

  • tuberous sclerosis 1 protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134904 RMC-6272 Inhibitor 97.42% Unkown
HY-131976 BVDV-IN-1 Inhibitor 98.51% Unkown
HY-RS15131 TSC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17222 Tsc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02096 CCL26 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-134922 NS1-IN-1 Inhibitor / Unkown
HY-RS23675 Tsc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tsc1 NCBI NCBI:7248