SERPINB3 - serpin family B member 3 Gene

Also Known as SCC; T4-A; SCCA1; SSCA1; SCCA-1; HsT1196; SCCA-PD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6317

About SERPINB3

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:63,655,197-63,661,893 (from NCBI)

This gene has 2 transcripts (splice variants), 223 orthologues and 36 paralogues. Restricted expression toward esophagus (RPKM 424.4).

Summary

Enables cysteine-type endopeptidase inhibitor activity; protease binding activity; and virus receptor activity. Involved in several processes, including autocrine signaling; paracrine signaling; and regulation of cellular protein metabolic process. Located in cytoplasmic vesicle; extracellular exosome; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SERPINB3 Products (1)

mRNA Protein Name
NM_006919.3 NP_008850.1 serpin B3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase inhibitor activity IMP
IMP: Inferred from mutant phenotype
21383048 GOA
enables protease binding IPI
IPI: Inferred from physical interaction
21383048 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
enables virus receptor activity IDA
IDA: Inferred from direct assay
12975381 GOA
Biological Process GO Annotation Evidence References Source
involved in autocrine signaling IMP
IMP: Inferred from mutant phenotype
20527027 GOA
involved in negative regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
21383048 GOA
involved in negative regulation of catalytic activity IDA
IDA: Inferred from direct assay
10956412 GOA
involved in negative regulation of endopeptidase activity IMP
IMP: Inferred from mutant phenotype
21383048 GOA
involved in negative regulation of peptidase activity IDA
IDA: Inferred from direct assay
12949073 GOA
involved in negative regulation of proteolysis IDA
IDA: Inferred from direct assay
12975381 GOA
involved in paracrine signaling IMP
IMP: Inferred from mutant phenotype
20527027 GOA
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
20527027 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
20527027 GOA
involved in positive regulation of endopeptidase activity IDA
IDA: Inferred from direct assay
20527027 GOA
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
20527027 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20527027 GOA
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
21383048 GOA
located in extracellular exosome IDA
IDA: Inferred from direct assay
21557262 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20527027 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINB3 Protein Structure

Serpin

Serpin: Serpin (serine protease inhibitor) (6 - 390)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
Protein Preferred Names Protein Names

serpin B3

  • protein T4-A

SERPINB3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SERPINB3 P29508 SERPINB4 Homo sapiens P48594
Anti Tag CoIP
33961781
Intra
SERPINB3 P29508 SERPINB4 Homo sapiens P48594
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SERPINB3 Proteins

Cat. No. Product Name Accession Purity
HY-P71142 Serpin B3 Protein, Human (HEK293, His) P29508 (M1-P390) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Squamous Cell Carcinoma

  • Epidermoid Carcinoma

  • Squamous Cell Cancer

  • Carcinoma, Squamous Cell

  • Squamous Cell Skin Cancer

  • Malignant Squamous Cell Tumor

  • Squamous Carcinoma

  • Squamous Cell Epithelioma

  • Carcinoma Squamous Cell

  • Neoplasms, Squamous Cell

  • Squamous Cell Carcinoma - Category

  • Malignant Squamous Cell Neoplasm

  • Squamous Cell Carcinoma Of Skin
Cervical Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of The Cervix Uteri

  • Squamous Cell Carcinoma Of Cervix
Otomycosis

  • Singapore Ear
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Cervical Cancer

  • Cervical Cancer, Somatic

  • Neoplasm Of Uterine Cervix

  • Cervix Cancer

  • Uterine Cervical Neoplasm

  • Cervical Neoplasm

  • Cervix Uteri Cancer

  • Tumor Of The Cervix Uteri

  • CERCA

  • Uterine Cervical Cancer

  • Neoplasms Cervical

  • Uterine Cervical Neoplasms

  • Cervical Cancers

  • Cancer, Cervical, Somatic

  • Malignant Tumor Of Cervix

  • Cervix Carcinoma
Psoriasis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12711 SERPINB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25592 Serpinb3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SERPINB3 RGD RGD:1549766
Others SERPINB3 NCBI