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XCL1 - X-C motif chemokine ligand 1 Gene

Also Known as LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6375

About XCL1

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:168,576,605-168,582,069 (from NCBI)

This gene has 1 transcript (splice variant), 116 orthologues and 25 paralogues. Low expression observed in reference dataset.

Summary

This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in Other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]

XCL1 Products (1)

mRNA	Protein	Name
NM_002995.3	NP_002986.1	lymphotactin precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables chemokine activity	IDA IDA: Inferred from direct assay	7602097	GOA
enables chemokine receptor binding	IDA IDA: Inferred from direct assay	9632725	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28381538	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11889129	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12949249	GOA
involved in cell-cell signaling	IDA IDA: Inferred from direct assay	7602097	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	12949249	GOA
involved in mature natural killer cell chemotaxis	IDA IDA: Inferred from direct assay	9029087	GOA
involved in negative regulation of CD4-positive, alpha-beta T cell proliferation	IDA IDA: Inferred from direct assay	10887101	GOA
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10887101	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10887101	GOA
involved in negative regulation of T cell cytokine production	IDA IDA: Inferred from direct assay	10887101	GOA
involved in negative regulation of T-helper 1 cell activation	IDA IDA: Inferred from direct assay	10887101	GOA
involved in negative regulation of interleukin-2 production	IDA IDA: Inferred from direct assay	10887101	GOA
involved in negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	10887101	GOA
involved in positive regulation of CD8-positive, alpha-beta T cell proliferation	IDA IDA: Inferred from direct assay	10887101	GOA
involved in positive regulation of T cell chemotaxis	IDA IDA: Inferred from direct assay	7602097	GOA
involved in positive regulation of T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	18832695	GOA
involved in positive regulation of granzyme A production	IDA IDA: Inferred from direct assay	18832695	GOA
involved in positive regulation of granzyme B production	IDA IDA: Inferred from direct assay	18832695	GOA
involved in positive regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	18832695	GOA
involved in positive regulation of natural killer cell chemotaxis	IDA IDA: Inferred from direct assay	9029087	GOA
involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	7602097	GOA
involved in positive regulation of transforming growth factor beta production	IDA IDA: Inferred from direct assay	18832695	GOA
involved in regulation of inflammatory response	IDA IDA: Inferred from direct assay	18832695	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	14734774	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XCL1 Protein Structure

IL8

0
100
114 a.a.

Protein Preferred Names	Protein Names
lymphotactin	SCM-1-alpha

XCL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	XCL1	P47992	PF4V1	Homo sapiens	P10720	Filter Binding	28381538
Intra	XCL1	P47992	PF4	Homo sapiens	P02776	Filter Binding	28381538
Intra	XCL1	P47992	PF4	Homo sapiens	P02776	SPR	28381538
Intra	XCL1	P47992	CCL5	Homo sapiens	P13501	Filter Binding	28381538
Intra	XCL1	P47992	CCL5	Homo sapiens	P13501	SPR	28381538
Intra	XCL1	P47992	CXCL12	Homo sapiens	P48061	SPR	28381538
Intra	XCL1	P47992	CCL13	Homo sapiens	Q99616	Filter Binding	28381538
Intra	XCL1	P47992	CCL26	Homo sapiens	Q9Y258	Filter Binding	28381538

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant XCL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7234	Lymphotactin/XCL1 Protein, Human	P47992 (G23-G114)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P71434	Lymphotactin/XCL1 Protein, Human (HEK293, Fc-His)	P47992 (V22-G114)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Sodoku Disease	Spirillosis Sodoku Spirillary Fever Rat-Bite Fever Rat-Bite Fever Due To Spirillum Minus Spirillary Rat-Bite Fever Sokosho
Renal Tuberculosis	Tuberculosis, Renal Tuberculosis Of Kidney Tuberculosis Renal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15866	XCL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16940	Xcl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23383	Xcl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	XCL1	RGD	RGD:620452
Mus musculus	XCL1	MGD	MGI:104593