Ube4b - ubiquitination factor E4B Gene

Also Known as UFD2; UFD2a; Ufd2p; mKIAA0684; D4Bwg0973e; 4930551I19Rik; 4933406G05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 63958

Summary

Enables ATP binding activity; enzyme binding activity; and ubiquitin-ubiquitin Ligase activity. Acts upstream of or within several processes, including protein ubiquitination; ubiquitin-dependent protein catabolic process; and ventricular trabecula myocardium morphogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human UBE4B (ubiquitination factor E4B). [provided by Alliance of Genome Resources, Apr 2022]

Ube4b Products (3)

mRNA Protein Name
NM_001404868.1 NP_001391797.1 ubiquitin conjugation factor E4 B isoform 2
NM_001404869.1 NP_001391798.1 ubiquitin conjugation factor E4 B isoform 3
NM_022022.4 NP_071305.2 ubiquitin conjugation factor E4 B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
23509263 MGI
enables enzyme binding IPI
IPI: Inferred from physical interaction
12504083 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12504083 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
11435423 MGI
enables ubiquitin-ubiquitin ligase activity IDA
IDA: Inferred from direct assay
11435423 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within neuron projection development IMP
IMP: Inferred from mutant phenotype
16314518 MGI
acts upstream of or within protein autoubiquitination IDA
IDA: Inferred from direct assay
23509263 MGI
acts upstream of or within protein catabolic process IMP
IMP: Inferred from mutant phenotype
16314518 MGI
acts upstream of or within protein monoubiquitination IDA
IDA: Inferred from direct assay
23509263 MGI
acts upstream of or within protein polyubiquitination IDA
IDA: Inferred from direct assay
11435423 MGI
acts upstream of or within protein polyubiquitination IMP
IMP: Inferred from mutant phenotype
16314518 MGI
acts upstream of or within protein ubiquitination IDA
IDA: Inferred from direct assay
15466860 MGI
acts upstream of or within response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
16314518 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
16314518 MGI
acts upstream of or within ventricular trabecula myocardium morphogenesis IMP
IMP: Inferred from mutant phenotype
16314518 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12504083 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11435423 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin conjugation factor E4 B

  • RING-type E3 ubiquitin transferase E4 B

  • ubiquitin fusion degradation protein 2

  • ubiquitination factor E4B, UFD2 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15372 UBE4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21073 Ube4b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27590 Ube4b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ube4b NCBI NCBI:10277