Casp7 - caspase 7 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64026

About Casp7

Primary_assembly 1: 255,437,172-255,476,729 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 218 orthologues, 12 paralogues and is associated with 26 phenotypes. Biased expression in Liver (RPKM 47.5), Heart (RPKM 47.1) and 9 other tissues.

Summary

Enables cysteine-type peptidase activity. Involved in several processes, including aging; leukocyte apoptotic process; and striated muscle cell differentiation. Located in cytosol and intracellular membrane-bounded organelle. Biomarker of several diseases, including endometritis; sciatic neuropathy; transient cerebral ischemia; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; colon cancer; and lung non-small cell carcinoma. Orthologous to human CASP7 (Caspase 7). [provided by Alliance of Genome Resources, Apr 2022]

Casp7 Products (1)

mRNA Protein Name
NM_022260.4 NP_071596.1 caspase-7

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cysteine-type peptidase activity IDA
IDA: Inferred from direct assay
17218406 RGD
Biological Process GO Annotation Evidence References Source
involved in leukocyte apoptotic process IEP
IEP: Inferred from expression pattern
26861981 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
18316105 RGD
involved in striated muscle cell differentiation IEP
IEP: Inferred from expression pattern
28899909 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp7 Protein Structure

CASc

CASc: cd00032 (59 - 300)

  • 0
  • 100
  • 200
  • 303 a.a.
Protein Preferred Names Protein Names

caspase-7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175177 XIAP-CASP7 PPI-IN-1 / Unkown
HY-RS01962 CASP7 Human Pre-designed siRNA Set A / Unkown
HY-RS01963 Casp7 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01964 Casp7 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp7 NCBI NCBI:840