Ascl1 - achaete-scute family bHLH transcription factor 1 Gene

Also Known as Mash1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64186

Summary

Enables double-stranded DNA binding activity and identical protein binding activity. Involved in several processes, including cellular response to magnetism; regulation of neuron differentiation; and response to epidermal growth factor. Predicted to be located in neuronal cell body and nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Biomarker of status epilepticus. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ascl1 Products (1)

mRNA Protein Name
NM_022384.2 NP_071779.1 achaete-scute homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
9521744 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
9521744 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to magnetism IEP
IEP: Inferred from expression pattern
19382241 RGD
involved in forebrain neuron differentiation IDA
IDA: Inferred from direct assay
17936272 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
11803116 RGD
involved in negative regulation of neuron differentiation IDA
IDA: Inferred from direct assay
17936272 RGD
involved in nervous system development IDA
IDA: Inferred from direct assay
11923194 RGD
involved in positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
10648228 RGD
involved in response to epidermal growth factor IEP
IEP: Inferred from expression pattern
9473334 RGD
involved in response to folic acid IEP
IEP: Inferred from expression pattern
19001765 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
11803116 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

achaete-scute homolog 1

  • achaete-scute complex homolog 1

  • achaete-scute complex homolog-like 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-155218 TMX-2172 Degrader 99.38% Unkown
HY-RS01078 ASCL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174778 Human ASCL1 mRNA / Unkown
HY-RS21486 Ascl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28004 Ascl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991871 Anti-ASCL1 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ascl1 NCBI NCBI:429