Ptges - prostaglandin E synthase Gene

Also Known as Pges; mPGES; mPGES-1; D2Ertd369e; 2410099E23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 64292

Summary

Enables prostaglandin-D synthase activity. Involved in prostaglandin biosynthetic process; regulation of fever generation; and sensory perception of pain. Acts upstream of or within negative regulation of cell population proliferation; positive regulation of prostaglandin secretion; and prostaglandin metabolic process. Located in cytoplasm and nuclear envelope lumen. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human PTGES (prostaglandin E synthase). [provided by Alliance of Genome Resources, Apr 2022]

Ptges Products (1)

mRNA Protein Name
NM_022415.3 NP_071860.1 prostaglandin E synthase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables prostaglandin-D synthase activity IDA
IDA: Inferred from direct assay
11795891 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
18485889 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
18485889 MGI
acts upstream of or within positive regulation of prostaglandin secretion IMP
IMP: Inferred from mutant phenotype
26828067 MGI
involved in prostaglandin biosynthetic process IDA
IDA: Inferred from direct assay
11795891 MGI
acts upstream of or within prostaglandin metabolic process IDA
IDA: Inferred from direct assay
10869354 MGI
involved in regulation of fever generation IMP
IMP: Inferred from mutant phenotype
14566340 MGI
involved in regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
12835414 MGI
involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
12835414 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12021206 MGI
located in nuclear envelope lumen IDA
IDA: Inferred from direct assay
10869354 MGI
NOT located in nucleus IDA
IDA: Inferred from direct assay
12021206 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prostaglandin E synthase

  • glutathione peroxidase PTGES

  • glutathione transferase PTGES

  • microsomal prostaglandin E synthase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11379 PTGES Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11380 PTGES2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11381 PTGES3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19734 Ptges Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19804 Ptges2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19805 Ptges3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26230 Ptges Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26300 Ptges2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26301 Ptges3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptges NCBI NCBI:9536