Mthfd1 - methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64300

Summary

Predicted to enable formate-tetrahydrofolate Ligase activity; methenyltetrahydrofolate cyclohydrolase activity; and methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity. Involved in nucleotide metabolic process; one-carbon metabolic process; and response to nitrogen dioxide. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; cleft lip; developmental cardiac valvular defect; neural tube defect (multiple); and tetralogy of Fallot. Orthologous to human MTHFD1 (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mthfd1 Products (1)

mRNA Protein Name
NM_022508.2 NP_071953.2 C-1-tetrahydrofolate synthase, cytoplasmic

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in one-carbon metabolic process IEP
IEP: Inferred from expression pattern
14597174 RGD
involved in response to nitrogen dioxide IEP
IEP: Inferred from expression pattern
3264158 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-1-tetrahydrofolate synthase, cytoplasmic

  • C1-THF synthase

  • C1-tetrahydrofolate synthase

  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetr

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-155950 TH9619 99.33% Phase 2

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-130251 DS18561882 99.95% Unkown
HY-101943 LY 345899 98.0% Unkown
HY-131943 DS44960156 Inhibitor ≥99.0% Unkown
HY-155219 TH9028 / Unkown
HY-149825 MTHFD2-IN-1 Inhibitor / Unkown
HY-149826 MTHFD2-IN-2 Inhibitor / Unkown
HY-149827 MTHFD2-IN-3 Inhibitor / Unkown
HY-149828 MTHFD2-IN-4 Inhibitor / Unkown
HY-149828A MTHFD2-IN-4 sodium Inhibitor / Unkown
HY-170361 MTHFD2-IN-5 Inhibitor / Unkown
HY-172910 MTHFD2-IN-6 / Unkown
HY-182355 MTHFD2-IN-7 Inhibitor / Unkown
HY-182356 MTHFD1/2-IN-1 Inhibitor / Unkown
HY-RS08774 MTHFD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08775 MTHFD1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-148014 TH7299 / Unkown
HY-RS17098 Mthfd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20214 Mthfd1l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23542 Mthfd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26720 Mthfd1l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mthfd1 NCBI NCBI:4522