Arf1 - ADP-ribosylation factor 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64310

Summary

Enables guanyl ribonucleotide binding activity; magnesium ion binding activity; and Phospholipase D activator activity. Involved in several processes, including Golgi to transport vesicle transport; positive regulation of transport; and postsynapse organization. Located in cytosol and late endosome. Is active in glutamatergic synapse and postsynaptic density. Colocalizes with COPI-coated vesicle; Golgi apparatus; and peroxisomal membrane. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARF1 (ADP ribosylation factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Arf1 Products (3)

mRNA Protein Name
NM_001414037.1 NP_001400966.1 ADP-ribosylation factor 1
NM_001414038.1 NP_001400967.1 ADP-ribosylation factor 1
NM_022518.5 NP_071963.1 ADP-ribosylation factor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GDP binding IDA
IDA: Inferred from direct assay
7552752 RGD
enables GTP binding IDA
IDA: Inferred from direct assay
7552752 RGD
enables magnesium ion binding IDA
IDA: Inferred from direct assay
7552752 RGD
enables phospholipase D activator activity IDA
IDA: Inferred from direct assay
7972129 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
23889934 RGD
Biological Process GO Annotation Evidence References Source
involved in Golgi to transport vesicle transport IDA
IDA: Inferred from direct assay
8978816 RGD
involved in actin filament organization IMP
IMP: Inferred from mutant phenotype
23889934 RGD
involved in dendritic spine organization IMP
IMP: Inferred from mutant phenotype
23889934 RGD
involved in long-term synaptic depression IDA
IDA: Inferred from direct assay
23889934 RGD
involved in lysosomal membrane organization IDA
IDA: Inferred from direct assay
9538255 RGD
involved in positive regulation of ER to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
15618550 RGD
involved in positive regulation of calcium ion-dependent exocytosis IDA
IDA: Inferred from direct assay
10657240 RGD
involved in positive regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
23889934 RGD
involved in positive regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
8294513 RGD
involved in positive regulation of late endosome to lysosome transport IMP
IMP: Inferred from mutant phenotype
21421027 RGD
involved in positive regulation of protein secretion IMP
IMP: Inferred from mutant phenotype
8294513 RGD
involved in positive regulation of sodium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
14563210 RGD
involved in postsynaptic actin cytoskeleton organization IDA
IDA: Inferred from direct assay
23889934 RGD
involved in postsynaptic actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
23889934 RGD
involved in regulation of Arp2/3 complex-mediated actin nucleation IDA
IDA: Inferred from direct assay
23889934 RGD
involved in regulation of phospholipid metabolic process IDA
IDA: Inferred from direct assay
10657240 RGD
involved in regulation of receptor internalization IDA
IDA: Inferred from direct assay
23889934 RGD
involved in synaptic vesicle budding IMP
IMP: Inferred from mutant phenotype
9590176 RGD
involved in very-low-density lipoprotein particle assembly IMP
IMP: Inferred from mutant phenotype
15618550 RGD
Cellular Component GO Annotation Evidence References Source
located in COPI-coated vesicle IDA
IDA: Inferred from direct assay
8496147 RGD
located in Golgi membrane IDA
IDA: Inferred from direct assay
8496147 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23889934 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
23889934 RGD
located in late endosome IDA
IDA: Inferred from direct assay
21421027 RGD
located in peroxisomal membrane IDA
IDA: Inferred from direct assay
16100119 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
23889934 RGD
is active in postsynaptic density IMP
IMP: Inferred from mutant phenotype
23889934 RGD
located in trans-Golgi network IDA
IDA: Inferred from direct assay
14684384 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ADP-ribosylation factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112473 Grassofermata Inhibitor 99.10% Unkown
HY-173280 Brefeldin A 4-O-nicotinate Inhibitor / Unkown
HY-175290 Arf1-GEFs-IN-1 Inhibitor / Unkown
HY-177269 CHNQD-01269 Inhibitor / Unkown
HY-P10157 ARF(1-22) / Unkown
HY-P10594 Myr-Arf1(2–17) / Unkown
HY-RS00894 ARF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10658 ARF1 (2-17) Inhibitor / Unkown
HY-RS17736 Arf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24201 Arf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arf1 NCBI NCBI:375