ARF1 - ADP ribosylation factor 1 Gene

Also Known as PVNH8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 375

About ARF1

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:228,082,708-228,099,212 (from NCBI)

This gene has 12 transcripts (splice variants), 219 orthologues, 30 paralogues and is associated with 3 phenotypes. Ubiquitous expression in placenta (RPKM 152.3), thyroid (RPKM 137.5) and 25 other tissues.

Summary

ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of Phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the Ras superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

ARF1 Products (4)

mRNA Protein Name
NM_001024226.2 NP_001019397.1 ADP-ribosylation factor 1
NM_001024227.1 NP_001019398.1 ADP-ribosylation factor 1
NM_001024228.2 NP_001019399.1 ADP-ribosylation factor 1
NM_001658.4 NP_001649.1 ADP-ribosylation factor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10198630 GOA
enables protein domain specific binding IMP
IMP: Inferred from mutant phenotype
12668765 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to virus IMP
IMP: Inferred from mutant phenotype
28389568 GOA
involved in intracellular copper ion homeostasis IMP
IMP: Inferred from mutant phenotype
21034850 GOA
Cellular Component GO Annotation Evidence References Source
located in cell leading edge IDA
IDA: Inferred from direct assay
22573891 GOA
part of protein-containing complex IMP
IMP: Inferred from mutant phenotype
12668765 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARF1 Protein Structure

Arf

Arf: ADP-ribosylation factor family (7 - 176)

  • 0
  • 100
  • 181 a.a.
Protein Preferred Names Protein Names

ADP-ribosylation factor 1

ARF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARF1 P84077 SPAG9 Homo sapiens O60271
SPR
19644450
Intra
ARF1 P84077 IQGAP1 Homo sapiens P46940
Anti Bait CoIP
36396045
Intra
ARF1 P84077 CYTH2 Homo sapiens Q99418
Fluorescence Spectr
17563369
Intra
ARF1 P84077 CYTH2 Homo sapiens Q99418
X-Ray Diffraction
14654833
Intra
ARF1 P84077 ARFIP2 Homo sapiens P53365
SLC
31467278
Intra
ARF1 P84077 ARFIP2 Homo sapiens P53365
Anti Tag CoIP
35271311
Intra
ARF1 P84077 ARFIP2 Homo sapiens P53365
Complementation
31467278
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ARF1 Proteins

Cat. No. Product Name Accession Purity
HY-P72089 ARF1 Protein, Human (His-GST, Myc) P84077 (G2-K181) ≥ 90%, as determined by reducing SDS-PAGE.

ARF1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84444 ARF1 Antibody (YA4141) IHC-P, ICC/IF, FC, ELISA Human
HY-P84444A ARF1 Antibody (YA4141)(PBS only) IHC-P, ICC/IF, FC, ELISA Human
HY-P85947 Actin_sarcomeric muscle Antibody (YA5639) IHC-P, WB, ICC/IF, ELISA Human, Mouse, Rat, Bovin, Pig, Chick

Related Diseases

Diseases Alias
Periventricular Nodular Heterotopia 8

  • PVNH8
Periventricular Nodular Heterotopia

  • Periventricular Heterotopia

  • Pvnh

  • Familial Nodular Heterotopia

  • Heterotopia, Periventricular

  • Periventricular Heterotopia, X-Linked
Cholera

  • Vibrio Cholerae Infection

  • Cholera - Vibrio Cholerae

  • Cholera Due To Vibrio Cholerae

  • Vibrio Cholerae

  • Cholera Syndrome

  • Asiatic Cholera

  • Epidemic Cholera
Legionnaire Disease

  • Legionnaires' Disease

  • Legionnaires Disease

  • Legionnaire Disease, Susceptibility To

  • Legionella

  • Legionella Pneumonia

  • Infection By Legionella Pneumophilia

  • Legionnaire'S Disease

  • Legionellosis

  • Legionaire Disease, Susceptibility To

  • Legionnaires Pneumonia
Nonparalytic Poliomyelitis

  • Acute Nonparalytic Poliomyelitis

  • Non-Paralytic Aseptic Meningitis
Legionellosis

  • Legionella Infection

  • Pontiac Fever

  • Legionnaires' Disease

  • Infection By Legionella Pneumophilia

  • Legionella Pneumophila Infection
Tangier Disease

  • Analphalipoproteinemia

  • High Density Lipoprotein Deficiency, Tangier Type

  • TGD

  • High Density Lipoprotein Deficiency, Type 1

  • Hdldt1

  • Familial High Density Lipoprotein Deficiency

  • A-Alphalipoprotein Neuropathy

  • Alpha High Density Lipoprotein Deficiency Disease

  • Cholesterol Thesaurismosis

  • Familial High Density Lipoprotein Deficiency Disease

  • Hdl Lipoprotein Deficiency Disease

  • Tangier Disease Neuropathy

  • Familial Alpha-Lipoprotein Deficiency

  • Familial High-Density Lipoprotein Deficiency 1

  • Primary Hypoalphalipoproteinemia 1

  • Analphalipo-Proteinemia

  • Familial Hypoalphalipo-Proteinemia

  • Familial Hypoalphalipoproteinemia

  • Lipoprotein Deficiency Disease, Hdl, Familial

  • Tangier Hereditary Neuropathy

  • Atp-Binding Cassette Transporter A1 Deficiency

  • Hdld1

  • High Density Lipoprotein Deficiency 1

  • Tangier Disease, Variant

  • Hypoalphalipoproteinemia, Familial

  • Familial Hdl Deficiency
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Warburg Micro Syndrome 1

  • Warburg Micro Syndrome

  • Micro Syndrome

  • Warbm

  • WARBM1

  • Warburg Sjo Fledelius Syndrome

  • Warburg-Sjo-Fledelius Syndrome

  • Micro Syndrome 1

  • Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism
Autoimmune Lymphoproliferative Syndrome

  • ALPS

  • Canale-Smith Syndrome

  • Autoimmune Lymphoproliferative Syndrome, Type Ia

  • Autoimmune Lymphoproliferative Syndrome, Type Ib

  • Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant

  • Css

  • Autoimmune Lymphoproliferative Syndrome, Type 1b

  • Autoimmune Lymphoproliferative Syndrome, Type 1a

  • Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant

  • Fas Deficiency

  • Autoimmune Lymphoproliferative Syndrome 1a

  • ALPS1A

  • Autoimmune Lymphoproliferative Syndrome Type Ia

  • Autoimmune Lymphoproliferative Syndrome 1b

  • ALPS1B

  • Autoimmune Lymphoproliferative Syndrome Type Ib
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112473 Grassofermata Inhibitor 99.10% Unkown
HY-173280 Brefeldin A 4-O-nicotinate Inhibitor / Unkown
HY-175290 Arf1-GEFs-IN-1 Inhibitor / Unkown
HY-177269 CHNQD-01269 Inhibitor / Unkown
HY-P10157 ARF(1-22) / Unkown
HY-P10594 Myr-Arf1(2–17) / Unkown
HY-RS00894 ARF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10658 ARF1 (2-17) Inhibitor / Unkown
HY-RS17736 Arf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24201 Arf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ARF1 MGD MGI:99431
Felis catus ARF1 VGNC VGNC:102161
Rattus norvegicus ARF1 RGD RGD:621270
Bos taurus ARF1 VGNC VGNC:50209
Others ARF1 NCBI