Sncg - synuclein, gamma Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64347

Summary

Enables alpha-tubulin binding activity and beta-tubulin binding activity. Involved in several processes, including cellular response to hydrostatic pressure; response to cocaine; and response to desipramine. Located in several cellular components, including axon terminus; neuronal cell body; and perinuclear region of cytoplasm. Biomarker of glaucoma and mental depression. Human ortholog(s) of this gene implicated in Lewy body dementia. Orthologous to human SNCG (synuclein gamma). [provided by Alliance of Genome Resources, Apr 2022]

Sncg Products (1)

mRNA Protein Name
NM_031688.2 NP_113876.2 gamma-synuclein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-tubulin binding IDA
IDA: Inferred from direct assay
18800064 RGD
enables beta-tubulin binding IDA
IDA: Inferred from direct assay
18800064 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18800064 RGD
Biological Process GO Annotation Evidence References Source
involved in aggressive behavior IEP
IEP: Inferred from expression pattern
15660669 RGD
involved in cellular response to hydrostatic pressure IEP
IEP: Inferred from expression pattern
11933054 RGD
involved in regulation of cellular response to stress IMP
IMP: Inferred from mutant phenotype
18936092 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
14622225 RGD
involved in response to desipramine IEP
IEP: Inferred from expression pattern
19818834 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18800064 RGD
Cellular Component GO Annotation Evidence References Source
located in axon terminus IDA
IDA: Inferred from direct assay
12127102 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
11716559 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18728752 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-synuclein

  • persyn

  • sensory neuron synuclein

  • synuclein, gamma (breast cancer-specific protein 1)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10844 ANK peptide / Unkown
HY-RS13487 SNCG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19382 Sncg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25874 Sncg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99828 Cofetuzumab 99.31% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sncg NCBI NCBI:6623