Htr6 - 5-hydroxytryptamine receptor 6 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64354

About Htr6

Primary_assembly 5: 151,296,662-151,311,912 reverse strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 55 orthologues, 35 paralogues and is associated with 5 phenotypes. Restricted expression toward (RPKM 8.2).

Summary

Enables G protein-coupled serotonin receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; long-term synaptic potentiation; and regulation of amine transport. Located in dendrite and plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human HTR6 (5-hydroxytryptamine receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Htr6 Products (1)

mRNA Protein Name
NM_024365.2 NP_077341.2 5-hydroxytryptamine receptor 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled serotonin receptor activity IDA
IDA: Inferred from direct assay
7680751 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
24614691 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IMP
IMP: Inferred from mutant phenotype
7680751 RGD
involved in learning IDA
IDA: Inferred from direct assay
17192775 RGD
involved in long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
19660530 RGD
involved in negative regulation of acetylcholine secretion, neurotransmission IMP
IMP: Inferred from mutant phenotype
16987217 RGD
involved in negative regulation of gamma-aminobutyric acid secretion IMP
IMP: Inferred from mutant phenotype
16987217 RGD
involved in negative regulation of glutamate secretion IMP
IMP: Inferred from mutant phenotype
16987217 RGD
involved in positive regulation of dopamine secretion IMP
IMP: Inferred from mutant phenotype
16987217 RGD
involved in positive regulation of gamma-aminobutyric acid secretion IMP
IMP: Inferred from mutant phenotype
19660530 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
17122082 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
10427606 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
10432491 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Htr6 Protein Structure

7tmA_5-HT6

7tmA_5-HT6: cd15054 (28 - 53)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (28 - 330)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (60 - 86)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (98 - 128)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (140 - 163)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (184 - 213)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (260 - 290)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (298 - 323)

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  • 400
  • 438 a.a.
Protein Preferred Names Protein Names

5-hydroxytryptamine receptor 6

  • 5-HT-6

  • 5-HT6

  • 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled

  • ST-B17

  • serotonin receptor 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06480 HTR6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06481 Htr6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06482 Htr6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Htr6 NCBI NCBI:3362