PGA3 - pepsinogen A3 Gene
Species: Homo sapiens
About PGA3
This gene has 8 transcripts (splice variants), 165 orthologues, 9 paralogues and is associated with 1 phenotype. Restricted expression toward stomach (RPKM 21519.3).
Summary
This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric Cancer. [provided by RefSeq, Jul 2015]
PGA3 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001079807.4 | NP_001073275.1 | pepsin A-3 preproprotein |
PGA3 Protein Structure
A1_Propeptide: A1 Propeptide (17 - 45)
Asp: Eukaryotic aspartyl protease (75 - 386)
- 0
- 100
- 200
- 300
- 388 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
pepsin A-3 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Atrophic Gastritis |
|
|
| Gastritis |
|
|
| Chief Cell Adenoma |
|
|
| Macular Degeneration, Age-Related, 10 |
|
|
| Gastric Cancer |
|
|
| Gastroesophageal Reflux |
|
|
| Primary Cutaneous Amyloidosis |
|
|
Related Agents
- Clinical Phase
- Pre-clinical Phase
Clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Phase
|
|---|---|---|---|---|
| HY-P990078 | Remternetug | Inhibitor | 99.00% | Phase 3 |
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-113491 | 3-Phosphoglyceric acid | Chemical | 99.88% | Unkown |
| HY-RS10371 | PGA3 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-114822 | Prostaglandin A3 | / | Unkown |
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