Inpp5e - inositol polyphosphate-5-phosphatase E Gene

Also Known as 72kDa; mKIAA0123; 1200002L24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 64436

Summary

Enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Acts upstream of or within inositol phosphate dephosphorylation; negative regulation of protein localization to cilium; and phosphatidylinositol dephosphorylation. Located in Golgi membrane; axoneme; and nucleus. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 1. Orthologous to human INPP5E (inositol polyphosphate-5-phosphatase E). [provided by Alliance of Genome Resources, Apr 2022]

Inpp5e Products (2)

mRNA Protein Name
NM_001290437.1 NP_001277366.1 phosphatidylinositol polyphosphate 5-phosphatase type IV isoform b
NM_033134.3 NP_149125.1 phosphatidylinositol polyphosphate 5-phosphatase type IV isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA
IDA: Inferred from direct assay
10806194 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cilium assembly IDA
IDA: Inferred from direct assay
34093381 MGI
acts upstream of or within negative regulation of protein localization to cilium IMP
IMP: Inferred from mutant phenotype
28154160 MGI
acts upstream of or within phosphatidylinositol dephosphorylation IDA
IDA: Inferred from direct assay
10806194 MGI
acts upstream of or within phosphatidylinositol metabolic process IDA
IDA: Inferred from direct assay
10806194 MGI
acts upstream of or within phosphatidylinositol metabolic process IMP
IMP: Inferred from mutant phenotype
28154160 MGI
acts upstream of or within response to inositol IDA
IDA: Inferred from direct assay
34093381 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
10806194 MGI
located in axoneme IDA
IDA: Inferred from direct assay
19668215 MGI
located in cilium IDA
IDA: Inferred from direct assay
28154160 MGI
located in nucleus IDA
IDA: Inferred from direct assay
26051944 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylinositol polyphosphate 5-phosphatase type IV

  • 72 kDa inositol polyphosphate 5-phosphatase

  • inositol polyphosphate-5-phosphatase, 72 kDa

  • phosphatidylinositol 4,5-bisphosphate 5-phosphatase

  • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06830 INPP5E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10770 PMPCA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21143 Inpp5e Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27660 Inpp5e Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Inpp5e NCBI NCBI:56623