Isl1 - ISL LIM homeobox 1 Gene

Also Known as Isl-1; isl-1=homeobox

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64444

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and Estrogen receptor binding activity. Involved in several processes, including cellular response to glucocorticoid stimulus; negative regulation of intracellular Estrogen receptor signaling pathway; and positive regulation of Insulin secretion. Located in nucleus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human ISL1 (ISL LIM homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Isl1 Products (1)

mRNA Protein Name
NM_017339.3 NP_059035.3 insulin gene enhancer protein ISL-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
19619559 RGD
enables LIM domain binding IMP
IMP: Inferred from mutant phenotype
26260513 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19619559 RGD
enables core promoter sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11043578 RGD
enables nuclear estrogen receptor binding IDA
IDA: Inferred from direct assay
11043578 RGD
enables nuclear receptor binding IDA
IDA: Inferred from direct assay
11043578 RGD
enables nuclear receptor binding IPI
IPI: Inferred from physical interaction
11043578 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9315627 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
1691825 RGD
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
18539116 RGD
Biological Process GO Annotation Evidence References Source
involved in axon regeneration IEP
IEP: Inferred from expression pattern
10363827 RGD
involved in cellular response to glucocorticoid stimulus IEP
IEP: Inferred from expression pattern
19619559 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
23270756 RGD
involved in negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
23270756 RGD
involved in negative regulation of intracellular estrogen receptor signaling pathway IDA
IDA: Inferred from direct assay
11043578 RGD
involved in negative regulation of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
23270756 RGD
involved in negative regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
11043578 RGD
involved in positive regulation of calcium ion import IMP
IMP: Inferred from mutant phenotype
29678908 RGD
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
23270756 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
11978636 RGD
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
29678908 RGD
involved in positive regulation of smoothened signaling pathway IDA
IDA: Inferred from direct assay
32544883 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16613990 RGD
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
18539116 RGD
involved in positive regulation of type B pancreatic cell apoptotic process IMP
IMP: Inferred from mutant phenotype
30341898 RGD
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
7759514 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
30341898 RGD
located in nucleus IDA
IDA: Inferred from direct assay
11043578 RGD
part of transcription regulator complex IDA
IDA: Inferred from direct assay
18539116 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

insulin gene enhancer protein ISL-1

  • ISL1 transcription factor LIM/homeodomain (islet-1)

  • ISL1 transcription factor, LIM/homeodomain 1

  • isl-1 homeobox

  • islet-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06931 ISL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174594 Human ISL1 mRNA / Unkown
HY-RS18481 Isl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24962 Isl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Isl1 NCBI NCBI:3670