Fzd2 - frizzled class receptor 2 Gene

Also Known as Fz-10; Fzd10

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64512

Summary

Enables Wnt-activated receptor activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; Wnt signaling pathway; and cellular response to vitamin D. Located in plasma membrane. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in omodysplasia 2. Orthologous to human FZD2 (Frizzled class receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Fzd2 Products (1)

mRNA Protein Name
NM_172035.2 NP_742032.2 frizzled-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Wnt receptor activity IDA
IDA: Inferred from direct assay
12471263 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
14688793 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
14688793 RGD
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
14688793 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger IDA
IDA: Inferred from direct assay
12471263 RGD
involved in Wnt signaling pathway, calcium modulating pathway IDA
IDA: Inferred from direct assay
12471263 RGD
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
24080158 RGD
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
1334084 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: Inferred from expression pattern
1334084 RGD
involved in cellular response to vitamin D IEP
IEP: Inferred from expression pattern
1334084 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
12471263 RGD
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
14688793 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

frizzled-2

  • Drosophila polarity gene (frizzled) homologue

  • Drosophila polarity gene homolog 2

  • frizzled family receptor 2

  • fz-2

  • rFz2

Fzd2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Fzd2 Q08464 Dlg4 Mus musculus Q62108
Imaging
12067714
Intra
Fzd2 Q08464 Fzd2 Rattus norvegicus Q08464
Beta Galactosidase
14688793
Intra
Fzd2 Q08464 Fzd2 Rattus norvegicus Q08464
BRET
14688793
Intra
Fzd2 Q08464 Fzd1 Rattus norvegicus Q08463
Beta Galactosidase
14688793
Intra
Fzd2 Q08464 Fzd1 Rattus norvegicus Q08463
BRET
14688793
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05178 FZD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18359 Fzd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24838 Fzd2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fzd2 NCBI NCBI:2535