Snap23 - synaptosome associated protein 23 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 64630

Summary

Enables SNAP receptor activity and syntaxin binding activity. Involved in several processes, including exocytic insertion of neurotransmitter receptor to postsynaptic membrane; regulation of exocytosis; and vesicle-mediated transport in synapse. Located in plasma membrane. Part of SNARE complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynapse. Orthologous to human SNAP23 (synaptosome associated protein 23). [provided by Alliance of Genome Resources, Apr 2022]

Snap23 Products (1)

mRNA	Protein	Name
NM_022689.2	NP_073180.1	synaptosomal-associated protein 23

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SNAP receptor activity	IDA IDA: Inferred from direct assay	19109692	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10373452	RGD
enables syntaxin binding	IPI IPI: Inferred from physical interaction	10051443	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IDA IDA: Inferred from direct assay	26839408	RGD
involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	26839408	RGD
involved in membrane fusion	IDA IDA: Inferred from direct assay	19109692	RGD
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	10051443	RGD
involved in regulation of exocytosis	IMP IMP: Inferred from mutant phenotype	11245593	RGD
involved in vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	11245593	RGD
involved in vesicle-mediated transport in synapse	IDA IDA: Inferred from direct assay	26839408	RGD
involved in vesicle-mediated transport in synapse	IMP IMP: Inferred from mutant phenotype	26839408	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	26839408	RGD
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	26839408	RGD
part of SNARE complex	IDA IDA: Inferred from direct assay	10051443	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20118925	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	20118925	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
synaptosomal-associated protein 23	SNAP-23 synaptosomal-associated protein, 23 kD vesicle-membrane fusion protein SNAP-23

Snap23 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Snap23	O70377	Ikbkb	Rattus norvegicus	Q9QY78	Anti Tag CoIP	18692471

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13473	SNAP23 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Snap23	NCBI	NCBI:8773