Ikbkb - inhibitor of nuclear factor kappa B kinase subunit beta Gene

Also Known as IKK2; AIM-1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 84351

About Ikbkb

Primary_assembly 16: 69,319,554-69,373,250 forward strand.mRatBN7.2:CM026989.1

This gene has 2 transcripts (splice variants), 198 orthologues, 3 paralogues and is associated with 36 phenotypes. Biased expression in Spleen (RPKM 138.6), Thymus (RPKM 121.8) and 9 other tissues.

Summary

Enables ATP binding activity. Contributes to IkappaB kinase activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; response to cholecystokinin; and response to lipopolysaccharide. Located in cytosol and intracellular membrane-bounded organelle. Part of IkappaB kinase complex. Used to study muscular atrophy and pneumonia. Biomarker of Alzheimer's disease; colitis; colon cancer; hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in breast cancer; combined immunodeficiency (multiple); dermatitis; prostate Cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Ikbkb Products (1)

mRNA	Protein	Name
NM_053355.3	NP_445807.2	inhibitor of nuclear factor kappa-B kinase subunit beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12133632	RGD
contributes to IkappaB kinase activity	IDA IDA: Inferred from direct assay	12592100	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15951441	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17419723	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	21618530	RGD
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	15939736	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15939736	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	15935065	RGD
involved in response to cholecystokinin	IDA IDA: Inferred from direct assay	12592100	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	19179648	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	17594812	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	12361703	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16331110	RGD
involved in skeletal muscle contraction	IEP IEP: Inferred from expression pattern	15888549	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of IkappaB kinase complex	IDA IDA: Inferred from direct assay	17419723	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ikbkb Protein Structure

STKc_IKK_beta

Ubl_IKKA_like

IKBKB_SDD

IKKbetaNEMObind

0
200
400
600
757 a.a.

Protein Preferred Names	Protein Names
inhibitor of nuclear factor kappa-B kinase subunit beta	I-kappa-B kinase 2 I-kappa-B-kinase beta IKK-B IKK-beta NFKBIKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta inhibitor of kappaB kinase beta inhibitor of nuclear factor kappa B kinase beta subunit nuclear factor NF-kappa-B inhibitor kinase beta serine/threonine protein kinase IKBKB

Ikbkb Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Ikbkb	Q9QY78	Snap23	Rattus norvegicus	O70377	Density Sedimentation	18692471

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06659	Ikbkb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06658	IKBKB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06660	Ikbkb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ikbkb	NCBI	NCBI:3551