Tfrc - transferrin receptor Gene

Also Known as Trfr

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64678

Summary

Enables HSP70 protein binding activity; chaperone binding activity; and Transferrin Receptor activity. Involved in several processes, including response to copper ion; response to manganese ion; and response to retinoic acid. Located in several cellular components, including cell surface; extracellular exosome; and recycling endosome membrane. Biomarker of duodenal ulcer; hepatocellular carcinoma; muscular atrophy; non-alcoholic fatty liver disease; and nutrition disease. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian Cancer. Orthologous to human TFRC (Transferrin Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Tfrc Products (1)

mRNA Protein Name
NM_022712.1 NP_073203.1 transferrin receptor protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Hsp70 protein binding IPI
IPI: Inferred from physical interaction
11133993 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
26728129 RGD
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
11133993 RGD
enables transferrin receptor activity IDA
IDA: Inferred from direct assay
12707050 RGD
Biological Process GO Annotation Evidence References Source
involved in acute-phase response IEP
IEP: Inferred from expression pattern
17417667 RGD
involved in response to copper ion IEP
IEP: Inferred from expression pattern
17298691 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
17091493 RGD
involved in response to iron ion IEP
IEP: Inferred from expression pattern
17060373 RGD
involved in response to manganese ion IEP
IEP: Inferred from expression pattern
17060373 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
18340409 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
18029484 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
15474526 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
21437659 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17145503 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
10747907 RGD
is active in postsynaptic recycling endosome membrane IDA
IDA: Inferred from direct assay
17145503 RGD
located in recycling endosome membrane IDA
IDA: Inferred from direct assay
10468577 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transferrin receptor protein 1

  • TR

  • tfR

  • tfR1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14431 TFRC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-173444 HDAC11-IN-3 99.70% Unkown
HY-RS23180 Tfrc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16743 Tfrc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990051 Delpacibart 98.06% Unkown
HY-P992144 Zareprumig Inhibitor 95.34% Unkown
HY-P992387 INA01 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tfrc NCBI NCBI:7037