P2ry12 - purinergic receptor P2Y12 Gene

Also Known as P2y12

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64803

About P2ry12

Primary_assembly 2: 143,481,430-143,523,361 reverse strand.mRatBN7.2:CM026975.1

This gene has 3 transcripts (splice variants), 182 orthologues, 6 paralogues and is associated with 22 phenotypes. Biased expression in Brain (RPKM 42.5), Adrenal (RPKM 41.2) and 9 other tissues.

Summary

Enables G protein-coupled ADP receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; inorganic cation transmembrane transport; and intracellular signal transduction. Located in basal plasma membrane; caveola; and external side of plasma membrane. Colocalizes with mitochondrion. Used to study abdominal aortic aneurysm and thrombosis. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12). [provided by Alliance of Genome Resources, Apr 2022]

P2ry12 Products (1)

mRNA Protein Name
NM_022800.1 NP_073637.1 P2Y purinoceptor 12

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled ADP receptor activity IDA
IDA: Inferred from direct assay
11196645 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled adenosine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12814667 RGD
involved in G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11196645 RGD
involved in calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
12080041 RGD
involved in calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
17299767 RGD
involved in cell projection organization IMP
IMP: Inferred from mutant phenotype
20091784 RGD
involved in cellular response to ATP IMP
IMP: Inferred from mutant phenotype
20091784 RGD
involved in cerebral cortex radial glia-guided migration IMP
IMP: Inferred from mutant phenotype
17299767 RGD
involved in glial cell migration IMP
IMP: Inferred from mutant phenotype
20681951 RGD
involved in lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
20091784 RGD
involved in negative regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
15056287 RGD
involved in negative regulation of norepinephrine secretion IMP
IMP: Inferred from mutant phenotype
19447154 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18183622 RGD
involved in positive regulation of cell adhesion mediated by integrin IGI
IGI: Inferred from genetic interaction
20091784 RGD
involved in positive regulation of chemotaxis IMP
IMP: Inferred from mutant phenotype
18183622 RGD
involved in positive regulation of integrin activation by cell surface receptor linked signal transduction IDA
IDA: Inferred from direct assay
20091784 RGD
involved in positive regulation of microglial cell migration IMP
IMP: Inferred from mutant phenotype
17299767 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
15056287 RGD
involved in positive regulation of ruffle assembly IMP
IMP: Inferred from mutant phenotype
17299767 RGD
involved in potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
12080041 RGD
involved in regulation of calcium ion transport IMP
IMP: Inferred from mutant phenotype
15579146 RGD
involved in regulation of chemotaxis IMP
IMP: Inferred from mutant phenotype
17299767 RGD
involved in response to axon injury IDA
IDA: Inferred from direct assay
14603465 RGD
Cellular Component GO Annotation Evidence References Source
located in basal plasma membrane IDA
IDA: Inferred from direct assay
21879346 RGD
located in caveola IDA
IDA: Inferred from direct assay
21879346 RGD
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
11196645 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2ry12 Protein Structure

7tmA_P2Y12

7tmA_P2Y12: cd15150 (31 - 315)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (31 - 58)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (64 - 89)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (102 - 132)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (144 - 166)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (191 - 220)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (240 - 268)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (281 - 305)

  • 0
  • 100
  • 200
  • 300
  • 343 a.a.
Protein Preferred Names Protein Names

P2Y purinoceptor 12

  • P2Y12 platelet ADP receptor

  • purinergic receptor P2Y, G-protein coupled, 12

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09919 P2RY12 Human Pre-designed siRNA Set A / Unkown
HY-RS09920 P2ry12 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09921 P2ry12 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P2ry12 NCBI NCBI:64805