Ireb2 - iron responsive element binding protein 2 Gene

Also Known as Irp2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64831

Summary

Enables 4 iron, 4 sulfur cluster binding activity; iron-responsive element binding activity; and regulatory region RNA binding activity. Involved in several processes, including cellular response to decreased oxygen levels; cellular response to epidermal growth factor stimulus; and response to iron ion. Located in axon; cytosol; and neuronal cell body. Used to study anemia. Biomarker of anemia; hyperinsulinism; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Ireb2 Products (1)

mRNA Protein Name
NM_022863.2 NP_074054.2 iron-responsive element-binding protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 4 iron, 4 sulfur cluster binding IDA
IDA: Inferred from direct assay
7665579 RGD
enables RNA binding IDA
IDA: Inferred from direct assay
21753061 RGD
enables iron-responsive element binding IDA
IDA: Inferred from direct assay
7665579 RGD
enables regulatory region RNA binding IPI
IPI: Inferred from physical interaction
7523370 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to epidermal growth factor stimulus IDA
IDA: Inferred from direct assay
10889193 RGD
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
16135072 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
22159112 RGD
involved in cellular response to iron(III) ion IDA
IDA: Inferred from direct assay
16135072 RGD
involved in cellular response to iron(III) ion IEP
IEP: Inferred from expression pattern
17469137 RGD
involved in cellular response to manganese ion IDA
IDA: Inferred from direct assay
16568477 RGD
involved in cellular response to manganese ion IEP
IEP: Inferred from expression pattern
17469137 RGD
involved in cellular response to mercaptoethanol IDA
IDA: Inferred from direct assay
16135072 RGD
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
22154532 RGD
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
7523370 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
24184442 RGD
involved in response to copper ion IEP
IEP: Inferred from expression pattern
24024382 RGD
involved in response to hypobaric hypoxia IEP
IEP: Inferred from expression pattern
27925282 RGD
involved in response to iron(II) ion IEP
IEP: Inferred from expression pattern
19943190 RGD
involved in response to iron(III) ion IDA
IDA: Inferred from direct assay
21753061 RGD
involved in response to kainic acid IEP
IEP: Inferred from expression pattern
16328268 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
19877527 RGD
involved in response to zinc ion IEP
IEP: Inferred from expression pattern
24024381 RGD
involved in skeletal muscle atrophy IEP
IEP: Inferred from expression pattern
23994517 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
12111837 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12111837 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

iron-responsive element-binding protein 2

  • IRE-BP 2

  • iron regulatory protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06901 IREB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20966 Ireb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27483 Ireb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ireb2 NCBI NCBI:3658