Pfkm - phosphofructokinase, muscle Gene

Also Known as PFK-A; Pfk-M; ATP-PFK

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65152

Summary

Enables several functions, including 6-phosphofructokinase activity; anion binding activity; and identical protein binding activity. Involved in fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; and glycolytic process. Predicted to be located in several cellular components, including apical plasma membrane; cytosol; and sperm principal piece. Predicted to be part of 6-phosphofructokinase complex. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Orthologous to human PFKM (phosphofructokinase, muscle). [provided by Alliance of Genome Resources, Apr 2022]

Pfkm Products (1)

mRNA Protein Name
NM_031715.2 NP_113903.2 ATP-dependent 6-phosphofructokinase, muscle type

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 6-phosphofructokinase activity IDA
IDA: Inferred from direct assay
12161 RGD
enables AMP binding IDA
IDA: Inferred from direct assay
12161 RGD
enables ATP binding IDA
IDA: Inferred from direct assay
12161 RGD
enables carbohydrate binding IDA
IDA: Inferred from direct assay
8593533 RGD
enables fructose-6-phosphate binding IDA
IDA: Inferred from direct assay
12161 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
2931076 RGD
enables phosphofructokinase activity IMP
IMP: Inferred from mutant phenotype
14522413 RGD
Biological Process GO Annotation Evidence References Source
involved in fructose 1,6-bisphosphate metabolic process IDA
IDA: Inferred from direct assay
12161 RGD
involved in fructose 6-phosphate metabolic process IDA
IDA: Inferred from direct assay
12161 RGD
involved in glycolytic process IDA
IDA: Inferred from direct assay
2931076 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-dependent 6-phosphofructokinase, muscle type

  • 6-phosphofructokinase type A

  • 6-phosphofructokinase, muscle type

  • phosphofructo-1-kinase isozyme A

  • phosphofructokinase 1

  • phosphofructokinase-A

  • phosphofructokinase-M

  • phosphohexokinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS18964 Pfkm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10366 PFKM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25454 Pfkm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pfkm NCBI NCBI:5213