Htra1 - HtrA serine peptidase 1 Gene

Also Known as Prss11

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65164

Summary

Predicted to enable identical protein binding activity and serine-type endopeptidase activity. Involved in dentinogenesis; negative regulation of defense response to virus; and positive regulation of epithelial cell proliferation. Located in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in CADASIL (multiple); hypertension; and macular degeneration (multiple). Orthologous to human HTRA1 (HtrA serine peptidase 1). [provided by Alliance of Genome Resources, Apr 2022]

Htra1 Products (1)

mRNA Protein Name
NM_031721.1 NP_113909.1 serine protease HTRA1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in dentinogenesis IEP
IEP: Inferred from expression pattern
22595117 RGD
involved in negative regulation of defense response to virus IMP
IMP: Inferred from mutant phenotype
15333144 RGD
involved in positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
15333144 RGD
Cellular Component GO Annotation Evidence References Source
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
22595117 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine protease HTRA1

  • high-temperature requirement A serine peptidase 1

  • protease serine 11

  • protease, serine, 11 (Igf binding)

  • serine protease 11

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99629 Galegenimab Inhibitor 99.91% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-163690 HTRA1-IN-1 Inhibitor 95.28% Unkown
HY-RS06486 HTRA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17551 Htra1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24010 Htra1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Htra1 NCBI NCBI:5654