Kcnd3 - potassium voltage-gated channel subfamily D member 3 Gene

Also Known as Kv4.3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65195

Summary

Enables voltage-gated Potassium Channel activity. Contributes to A-type (transient outward) Potassium Channel activity. Involved in cellular response to BMP stimulus; potassium ion export across plasma membrane; and potassium ion import across plasma membrane. Located in several cellular components, including caveola; neuronal cell body; and perinuclear endoplasmic reticulum. Is integral component of plasma membrane. Part of voltage-gated Potassium Channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to human KCND3 (potassium voltage-gated channel subfamily D member 3). [provided by Alliance of Genome Resources, Apr 2022]

Kcnd3 Products (3)

mRNA Protein Name
NM_001270962.1 NP_001257891.1 potassium voltage-gated channel subfamily D member 3 isoform 1 precursor
NM_001270963.1 NP_001257892.1 potassium voltage-gated channel subfamily D member 3 isoform 2 precursor
NM_031739.3 NP_113927.2 potassium voltage-gated channel subfamily D member 3 isoform 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables A-type (transient outward) potassium channel activity IDA
IDA: Inferred from direct assay
8831489 RGD
enables A-type (transient outward) potassium channel activity IMP
IMP: Inferred from mutant phenotype
12150935 RGD
enables monoatomic ion channel activity IDA
IDA: Inferred from direct assay
10325948 RGD
enables potassium channel activity IDA
IDA: Inferred from direct assay
10325948 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10794667 RGD
enables voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
10325948 RGD
enables voltage-gated potassium channel activity IMP
IMP: Inferred from mutant phenotype
12150935 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to BMP stimulus IMP
IMP: Inferred from mutant phenotype
23747723 RGD
involved in potassium ion export across plasma membrane IDA
IDA: Inferred from direct assay
26016905 RGD
involved in potassium ion import across plasma membrane IDA
IDA: Inferred from direct assay
27198182 RGD
involved in potassium ion transport IDA
IDA: Inferred from direct assay
8831489 RGD
Cellular Component GO Annotation Evidence References Source
located in caveola IDA
IDA: Inferred from direct assay
20224290 RGD
located in dendrite IDA
IDA: Inferred from direct assay
20849929 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15738276 RGD
located in perinuclear endoplasmic reticulum IDA
IDA: Inferred from direct assay
12967630 RGD
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
20224290 RGD
part of voltage-gated potassium channel complex IPI
IPI: Inferred from physical interaction
27198182 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily D member 3

  • potassium channel, voltage-gated Shal-related subfamily D, member 3

  • potassium voltage gated channel, Shal-related family, member 3

  • potassium voltage-gated channel, Shal-related subfamily, member 3

  • voltage-gated potassium channel subunit Kv4.3

Kcnd3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Kcnd3 Q62897 KCNIP1 Homo sapiens Q9NZI2
Pull Down
17057713
Cross
Kcnd3 Q62897 KCNIP1 Homo sapiens Q9NZI2
X-Ray Diffraction
17057713
Cross
Kcnd3 Q62897 KCNIP1 Homo sapiens Q9NZI2
SAXS
17057713
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07114 KCND3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20972 Kcnd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27489 Kcnd3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnd3 NCBI NCBI:3752