Kcnn4 - potassium calcium-activated channel subfamily N member 4 Gene

Also Known as rSK4; KCa3.1; rKCNN4c

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65206

Summary

Enables Intermediate conductance calcium-activated Potassium Channel activity. Involved in anion transport and potassium ion export across plasma membrane. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and membrane raft. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 2. Orthologous to human KCNN4 (potassium calcium-activated channel subfamily N member 4). [provided by Alliance of Genome Resources, Apr 2022]

Kcnn4 Products (4)

mRNA Protein Name
NM_001270701.1 NP_001257630.1 intermediate conductance calcium-activated potassium channel protein 4 isoform a
NM_001270702.1 NP_001257631.1 intermediate conductance calcium-activated potassium channel protein 4 isoform b
NM_001270703.1 NP_001257632.1 intermediate conductance calcium-activated potassium channel protein 4 isoform c
NM_023021.2 NP_075410.2 intermediate conductance calcium-activated potassium channel protein 4 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables intermediate conductance calcium-activated potassium channel activity IDA
IDA: Inferred from direct assay
10532960 RGD
enables inward rectifier potassium channel activity IDA
IDA: Inferred from direct assay
21463632 RGD
Biological Process GO Annotation Evidence References Source
involved in cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
25715999 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
26439051 RGD
involved in hepatocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
27354175 RGD
involved in monoatomic anion transport IDA
IDA: Inferred from direct assay
20616305 RGD
involved in mononuclear cell migration IMP
IMP: Inferred from mutant phenotype
25715999 RGD
involved in negative regulation of cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
28679649 RGD
involved in negative regulation of cell volume IMP
IMP: Inferred from mutant phenotype
27354175 RGD
involved in negative regulation of hepatic stellate cell proliferation IMP
IMP: Inferred from mutant phenotype
27354175 RGD
involved in positive regulation of G0 to G1 transition IMP
IMP: Inferred from mutant phenotype
26439051 RGD
involved in positive regulation of microglial cell activation IMP
IMP: Inferred from mutant phenotype
21750563 RGD
involved in positive regulation of p38MAPK cascade IMP
IMP: Inferred from mutant phenotype
28679649 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
24312257 RGD
involved in potassium ion export across plasma membrane IDA
IDA: Inferred from direct assay
12606302 RGD
involved in potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
10532960 RGD
involved in potassium ion transport IDA
IDA: Inferred from direct assay
10532960 RGD
involved in regulation of angiotensin levels in blood IMP
IMP: Inferred from mutant phenotype
25715999 RGD
involved in regulation of monocyte chemotactic protein-1 production IMP
IMP: Inferred from mutant phenotype
25715999 RGD
involved in regulation of renin secretion into blood stream IMP
IMP: Inferred from mutant phenotype
25715999 RGD
involved in regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
26439051 RGD
involved in regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
25715999 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
28679649 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
21463632 RGD
involved in response to tetrachloromethane IEP
IEP: Inferred from expression pattern
27354175 RGD
involved in vascular associated smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
21463632 RGD
involved in vascular associated smooth muscle cell proliferation IEP
IEP: Inferred from expression pattern
21463632 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
12606302 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
12606302 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15680700 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

intermediate conductance calcium-activated potassium channel protein 4

  • IK1

  • KCa4

  • SK4

  • SKCa 4

  • SKCa4

  • intermediate conductance K channel

  • intermediate-conductance Ca-activated K channel

  • potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4

  • potassium intermediate/small conductance c

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P4121 L17E 99.88% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W403607 CBIQ Activator 99.94% Unkown
HY-RS07172 KCNN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20432 Kcnn4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26941 Kcnn4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnn4 NCBI NCBI:3783