SLC15A1 - solute carrier family 15 member 1 Gene

Homo sapiens

Also known as PEPT1; HPECT1; HPEPT1

Gene ID: 6564 | Gene type: protein coding

About SLC15A1

Cytogenetic location: 13q32.2-q32.3 Genomic coordinates (GRCh38): 13:98,683,801-98,752,672 (from NCBI)

This gene has 2 transcripts (splice variants), 264 orthologues and 4 paralogues. Biased expression in small intestine (RPKM 105.5), duodenum (RPKM 76.1) and 2 other tissues.

Summary

This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]

SLC15A1 Products(1)

mRNA	Protein	Name
NM_005073.4	NP_005064.1	solute carrier family 15 member 1

SLC15A1 Protein Structure

PTR2

0
200
400
600
708 a.a.

Protein Preferred Names

Protein Names

solute carrier family 15 member 1

Caco-2 oligopeptide transporter

Related Diseases

Diseases

Alias

Short Bowel Syndrome

Short Gut Syndrome	Acquired Short Bowel Syndrome
Secondary Short Bowel Syndrome	Short Bowel Nos

Hartnup Disorder

Hartnup Disease	HND
Neutral 1 Amino Acid Transport Defect	Neutral Amino Acid Transport Defect
Deficiency Of Tryptophan Oxygenase	Hartnup'S Disease
Aminoaciduria, Hartnup Type	Disorder Of Neutral Amino Acid Transport

Meckel Diverticulum

Meckel'S Diverticulum

Persistent Vitelline Duct

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Iminoglycinuria

Iminoglycinuria, Digenic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13012	SLC15A1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC15A1	VGNC	VGNC:46232
Mus musculus	SLC15A1	MGD	MGI:1861376
Macaca mulatta	SLC15A1	VGNC	VGNC:77393
Bos taurus	SLC15A1	VGNC	VGNC:34679
Rattus norvegicus	SLC15A1	RGD	RGD:621736
Felis catus	SLC15A1	VGNC	VGNC:65200

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