SLC15A1 - solute carrier family 15 member 1 Gene

Also Known as PEPT1; HPECT1; HPEPT1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6564

About SLC15A1

Cytogenetic location: 13q32.2-q32.3 Genomic coordinates (GRCh38): 13:98,683,801-98,752,672 (from NCBI)

This gene has 2 transcripts (splice variants), 264 orthologues and 4 paralogues. Biased expression in small intestine (RPKM 105.5), duodenum (RPKM 76.1) and 2 other tissues.

Summary

This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]

SLC15A1 Products (1)

mRNA	Protein	Name
NM_005073.4	NP_005064.1	solute carrier family 15 member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables dipeptide transmembrane transporter activity	IDA IDA: Inferred from direct assay	8914574	GOA
enables peptide:proton symporter activity	IDA IDA: Inferred from direct assay	7896779	GOA
enables tripeptide transmembrane transporter activity	IDA IDA: Inferred from direct assay	9835627	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in dipeptide import across plasma membrane	IDA IDA: Inferred from direct assay	18367661	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	28408210	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23137377	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC15A1 Protein Structure

PTR2

0
200
400
600
708 a.a.

Protein Preferred Names	Protein Names
solute carrier family 15 member 1	Caco-2 oligopeptide transporter

Related Diseases

Diseases	Alias
Short Bowel Syndrome	Short Gut Syndrome Acquired Short Bowel Syndrome Secondary Short Bowel Syndrome Short Bowel Nos
Hartnup Disorder	Hartnup Disease HND Neutral 1 Amino Acid Transport Defect Neutral Amino Acid Transport Defect Deficiency Of Tryptophan Oxygenase Hartnup'S Disease Aminoaciduria, Hartnup Type Disorder Of Neutral Amino Acid Transport
Meckel Diverticulum	Meckel'S Diverticulum Persistent Vitelline Duct
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Iminoglycinuria	Iminoglycinuria, Digenic IG

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-W010162	H-Ala-Ala-OH		98.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D3210	DCM-KPV		/	Unkown
HY-RS13012	SLC15A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC15A1	VGNC	VGNC:46232
Mus musculus	SLC15A1	MGD	MGI:1861376
Macaca mulatta	SLC15A1	VGNC	VGNC:77393
Bos taurus	SLC15A1	VGNC	VGNC:34679
Rattus norvegicus	SLC15A1	RGD	RGD:621736
Felis catus	SLC15A1	VGNC	VGNC:65200
Others	SLC15A1	NCBI