Clstn1 - calsyntenin 1 Gene

Also Known as Cst-1; Cstn1; 1810034E21Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 65945

Summary

Predicted to enable X11-like protein binding activity; amyloid-beta binding activity; and Kinesin binding activity. Involved in neurotransmitter receptor transport to postsynaptic membrane; regulation of synapse maturation; and vesicle-mediated transport in synapse. Acts upstream of or within positive regulation of synapse assembly; positive regulation of synaptic transmission; and regulation of cell growth. Located in several cellular components, including postsynaptic density; postsynaptic endosome; and postsynaptic membrane. Is integral component of membrane. Is active in glutamatergic synapse. Is expressed in central nervous system; intestine; and retina. Orthologous to human CLSTN1 (calsyntenin 1). [provided by Alliance of Genome Resources, Apr 2022]

Clstn1 Products (2)

mRNA	Protein	Name
NM_001290989.1	NP_001277918.1	calsyntenin-1 isoform 2 precursor
NM_023051.5	NP_075538.1	calsyntenin-1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17332754	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in neurotransmitter receptor transport to postsynaptic membrane	IDA IDA: Inferred from direct assay	24966372	MGI
involved in neurotransmitter receptor transport to postsynaptic membrane	IEP IEP: Inferred from expression pattern	24966372	MGI
involved in neurotransmitter receptor transport to postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	24966372	MGI
acts upstream of or within positive regulation of synapse assembly	IGI IGI: Inferred from genetic interaction	24613359	MGI
acts upstream of or within positive regulation of synaptic transmission	IGI IGI: Inferred from genetic interaction	24613359	MGI
acts upstream of or within regulation of cell growth	IGI IGI: Inferred from genetic interaction	24613359	MGI
involved in regulation of synapse maturation	IDA IDA: Inferred from direct assay	24966372	MGI
involved in regulation of synapse maturation	IEP IEP: Inferred from expression pattern	24966372	MGI
involved in regulation of synapse maturation	IMP IMP: Inferred from mutant phenotype	24966372	MGI
involved in vesicle-mediated transport in synapse	IDA IDA: Inferred from direct assay	24966372	MGI
involved in vesicle-mediated transport in synapse	IEP IEP: Inferred from expression pattern	24966372	MGI
involved in vesicle-mediated transport in synapse	IMP IMP: Inferred from mutant phenotype	24966372	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	24613359	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	11161476	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	24966372	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	24966372	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	24966372	MGI
located in membrane	IDA IDA: Inferred from direct assay	11161476	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	24613359	MGI
is active in postsynaptic endosome	IDA IDA: Inferred from direct assay	24966372	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	11161476	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
calsyntenin-1	alc-alpha alcadein alpha

Clstn1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Clstn1	Q9EPL2	Klc1	Mus musculus	Q8CD76	Y2H	17332754
Intra	Clstn1	Q9EPL2	Klc1	Mus musculus	Q8CD76	Anti Bait CoIP	17332754

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-176712	GSNOR-IN-1	Inhibitor	/	Unkown
HY-RS02840	CLSTN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20146	Clstn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26650	Clstn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Clstn1	NCBI	NCBI:22883