Iscu - iron-sulfur cluster assembly enzyme Gene

Also Known as Nifu; ISCU2; Nifun; 2310020H20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66383

Summary

Predicted to enable 2 iron, 2 sulfur cluster binding activity; ferrous iron binding activity; and molecular adaptor activity. Predicted to be involved in several processes, including negative regulation of iron ion import across plasma membrane; positive regulation of aconitate hydratase activity; and positive regulation of mitochondrial electron transport, NADH to ubiquinone. Located in mitochondrion. Orthologous to human ISCU (iron-sulfur cluster assembly enzyme). [provided by Alliance of Genome Resources, Apr 2022]

Iscu Products (2)

mRNA Protein Name
NM_001363317.1 NP_001350246.1 iron-sulfur cluster assembly enzyme ISCU, mitochondrial isoform 2
NM_025526.5 NP_079802.1 iron-sulfur cluster assembly enzyme ISCU, mitochondrial isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
29097656 MGI
Biological Process GO Annotation Evidence References Source
involved in [4Fe-4S] cluster assembly IDA
IDA: Inferred from direct assay
25597503 MGI
Cellular Component GO Annotation Evidence References Source
part of mitochondrial [2Fe-2S] assembly complex IDA
IDA: Inferred from direct assay
21298097 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
17597094 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

iron-sulfur cluster assembly enzyme ISCU, mitochondrial

  • IscU iron-sulfur cluster scaffold homolog

  • nifU-like N-terminal domain-containing protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145413 BRD2889 Inhibitor / Unkown
HY-RS06928 ISCU Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18618 Iscu Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25104 Iscu Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Iscu NCBI NCBI:23479