Sln - sarcolipin Gene

Also Known as 2310045A07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66402

Summary

Sarcoplasmic reticulum CA(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of CA(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum CA(2+)-ATPases. The transmembrane protein interacts with CA(2+)-ATPases and reduces the accumulation of CA(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]

Sln Products (1)

mRNA Protein Name
NM_025540.2 NP_079816.1 sarcolipin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
27923914 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of ATPase-coupled calcium transmembrane transporter activity IDA
IDA: Inferred from direct assay
27923914 MGI
acts upstream of or within negative regulation of calcium ion binding IDA
IDA: Inferred from direct assay
27923914 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
22961106 MGI
involved in regulation of ATPase-coupled calcium transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
21697544 MGI
involved in regulation of relaxation of muscle IMP
IMP: Inferred from mutant phenotype
21697544 MGI
involved in sarcoplasmic reticulum calcium ion transport IMP
IMP: Inferred from mutant phenotype
21697544 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
27923914 MGI
located in sarcoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
26816378 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sarcolipin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-147425A Zerlasiran sodium Inhibitor 95.52% Phase 2
HY-147278A Manusiran sodium Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-113217 Cholesteryl oleate 99.0% Unkown
HY-113217S Cholesteryl oleate-d7 ≥99.0% Unkown
HY-164390 6′SLN 99.87% Unkown
HY-W013122 Cholesteryl n-butyrate 99.97% Unkown
HY-147425 Zerlasiran Inhibitor 95.52% Unkown
HY-113217S1 Cholesteryl oleate-d7-1 / Unkown
HY-147278 Manusiran Inhibitor / Unkown
HY-147425C Zerlasiran sodium scrambled negative control / Unkown
HY-147425D FAM labled Zerlasiran sodium Inhibitor / Unkown
HY-147425E Cy3 labled Zerlasiran sodium Inhibitor / Unkown
HY-P11025 TMVP1446 / Unkown
HY-P11026 DOTA-TMVP1446 / Unkown
HY-RS13381 SLN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123779 RWJ-49815 Inhibitor / Unkown
HY-168392 Propylene glycol monopalmitate / Unkown
HY-RS17627 Sln Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24087 Sln Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sln NCBI NCBI:6588