Oma1 - OMA1 zinc metallopeptidase Gene

Also Known as MPRP-1; ZMPOMA1; 2010001O09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67013

Summary

Enables metalloendopeptidase activity. Involved in several processes, including diet induced thermogenesis; energy homeostasis; and protein processing. Acts upstream of or within cristae formation. Located in mitochondrial inner membrane. Is expressed in alimentary system; liver lobe; and nose. Orthologous to human OMA1 (OMA1 zinc metallopeptidase). [provided by Alliance of Genome Resources, Apr 2022]

Oma1 Products (1)

mRNA Protein Name
NM_025909.3 NP_080185.1 metalloendopeptidase OMA1, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables metalloendopeptidase activity IDA
IDA: Inferred from direct assay
24550258 MGI
enables metalloendopeptidase activity IMP
IMP: Inferred from mutant phenotype
22433842 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cristae formation IGI
IGI: Inferred from genetic interaction
20038678 MGI
involved in diet induced thermogenesis IMP
IMP: Inferred from mutant phenotype
22433842 MGI
involved in energy homeostasis IMP
IMP: Inferred from mutant phenotype
22433842 MGI
involved in glucose metabolic process IMP
IMP: Inferred from mutant phenotype
22433842 MGI
involved in lipid metabolic process IMP
IMP: Inferred from mutant phenotype
22433842 MGI
involved in mitochondrial protein processing IDA
IDA: Inferred from direct assay
24550258 MGI
acts upstream of or within mitochondrial protein processing IMP
IMP: Inferred from mutant phenotype
20038678 MGI
involved in mitochondrial respiratory chain complex assembly IMP
IMP: Inferred from mutant phenotype
26365306 MGI
acts upstream of or within mitochondrion organization IGI
IGI: Inferred from genetic interaction
20038678 MGI
involved in negative regulation of mitochondrial fusion IMP
IMP: Inferred from mutant phenotype
22433842 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
22433842 MGI
involved in protein autoprocessing IDA
IDA: Inferred from direct assay
24550258 MGI
involved in zymogen activation IDA
IDA: Inferred from direct assay
24550258 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
24550258 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
20038678 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metalloendopeptidase OMA1, mitochondrial

  • OMA1 homolog, zinc metallopeptidase

  • overlapping with the m-AAA protease 1 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16953 Oma1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180786 DdBIC / Unkown
HY-RS09781 OMA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23396 Oma1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Oma1 NCBI NCBI:115209