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OMA1 - OMA1 zinc metallopeptidase Gene

Also Known as DAB1; MPRP1; MPRP-1; YKR087C; ZMPOMA1; peptidase; 2010001O09Rik

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 115209

About OMA1

Cytogenetic location: 1p32.2-p32.1 Genomic coordinates (GRCh38): 1:58,480,719-58,546,726 (from NCBI)

This gene has 11 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in kidney (RPKM 9.7), prostate (RPKM 9.5) and 25 other tissues.

Summary

Enables metalloendopeptidase activity. Involved in several processes, including HRI-mediated signaling; proteolysis; and regulation of mitochondrion organization. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]

OMA1 Products (1)

mRNA	Protein	Name
NM_145243.5	NP_660286.1	metalloendopeptidase OMA1, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	25275009	GOA
enables metalloendopeptidase activity	IMP IMP: Inferred from mutant phenotype	20038677	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in HRI-mediated signaling	IDA IDA: Inferred from direct assay	32132706	GOA
involved in cellular response to stress	IDA IDA: Inferred from direct assay	32132706	GOA
involved in integrated stress response signaling	IDA IDA: Inferred from direct assay	32132706	GOA
involved in mitochondrial protein processing	IDA IDA: Inferred from direct assay	25275009	GOA
involved in mitochondrial protein processing	IMP IMP: Inferred from mutant phenotype	25605331	GOA
involved in negative regulation of mitochondrial fusion	IMP IMP: Inferred from mutant phenotype	20038677	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	25275009	GOA
involved in protein quality control for misfolded or incompletely synthesized proteins	IMP IMP: Inferred from mutant phenotype	20038677	GOA
involved in regulation of cristae formation	IDA IDA: Inferred from direct assay	25275009	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	32132707	GOA
is active in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	32132706	GOA
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	20038677	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OMA1 Protein Structure

Peptidase_M48

0
100
200
300
400
500
524 a.a.

Protein Preferred Names	Protein Names
metalloendopeptidase OMA1, mitochondrial	OMA1 homolog, zinc metallopeptidase

Recombinant OMA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72010	OMA1 Protein, Human (Cell-Free, His-SUMO)	Q96E52-1 (H14-S524)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia 28	Spinocerebellar Ataxia Type 28 SCA28 Ataxia, Spinocerebellar, Type 28
3-Methylglutaconic Aciduria, Type Iii	Optic Atrophy 3-Methylglutaconic Aciduria Type 3 Costeff Syndrome Mga3 Costeff Optic Atrophy Syndrome Optic Atrophy Plus Syndrome Infantile Optic Atrophy With Chorea And Spastic Paraplegia 3-Methylglutaconic Aciduria Type Iii Autosomal Recessive Optic Atrophy Plus Syndrome Autosomal Recessive Optic Atrophy Type 3 Opa3 Defect MGCA3 Mga, Type Iii Iraqi Jewish Optic Atrophy Plus Mga Type Iii Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia Iraqi-Jewish 'Optic Atrophy Plus' Optic Atrophy 3, Autosomal Recessive Opa3, Autosomal Recessive Opa3-Related 3-Methylglutaconic Aciduria Iraqi-Jewish Optic Atrophy Plus Atrophy Of Optic Disc 3-Alpha Methylglutaconic Aciduria Type Iii Optic Atrophy 3 Optic Atrophy Infantile With Chorea And Spastic Paraplegia Autosomal Recessive Opa3 Autosomal Recessive Optic Atrophy 3 3-Methylglutaconic Aciduria 3 3-Alpha-Methylglutaconic Aciduria Type 3 Optic Atrophy 3 Autosomal Recessive Atrophy, Optic Atrophy, Optic, Plus Syndrome Optic Nerve Atrophy Primary Optic Atrophy Oa - [Optic Atrophy] Second Cranial Nerve Atrophy Second Cranium Nerve Atrophy
Behr Syndrome	BEHRS Abortive Cerebellar Ataxia Optic Atrophy, Infantile Hereditary, With Neurologic Abnormalities Optic Atrophy, Infantile Hereditary, Behr Complicated Form Of Optic Atrophy In Early Childhood, Associated With Ataxia, Spasticity, Mental Retardation, And Posterior Column Sensory Loss Obsolete: Behr Syndrome Optic Atrophy In Early Childhood, Associated With Ataxia, Spasticity, Intellectual Disability, And Posterior Column Sensory Loss Infantile Hereditary Optic Atrophy With Neurologic Abnormalities
Optic Atrophy 7 With Or Without Auditory Neuropathy	Optic Atrophy 7 OPA7 Autosomal Recessive Optic Atrophy, Opa7 Type Optic Atrophy-7 Atrophy, Optic, Type 7, With/Without Auditory Neuropathy
Combined Oxidative Phosphorylation Deficiency 33	COXPD33
Optic Atrophy 11	OPA11 Atrophy, Optic, Type 11
Optic Nerve Disease	Optic Neuropathy Disorder Of The Second Nerve Optic Nerve Disorder Optic Nerve Abnormality Of The Optic Nerve Optic Nerve Disorders Neuropathy, Optic Disorder Of The Optic Nerve
Spastic Ataxia	Spax Ataxia, Spastic
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16953	Oma1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-180786	DdBIC		/	Unkown
HY-RS09781	OMA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23396	Oma1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	OMA1	RGD	RGD:1304821
Bos taurus	OMA1	VGNC	VGNC:32428
Macaca mulatta	OMA1	VGNC	VGNC:75485
Canis familiaris	OMA1	VGNC	VGNC:44121
Mus musculus	OMA1	MGD	MGI:1914263
Felis catus	OMA1	VGNC	VGNC:63967
Others	OMA1	NCBI