Rbpj - recombination signal binding protein for immunoglobulin kappa J region Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 679028

Summary

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein N-terminus binding activity. Involved in several processes, including negative regulation of smooth muscle cell apoptotic process; negative regulation of smooth muscle cell migration; and positive regulation of smooth muscle cell proliferation. Located in nucleus. Part of protein-DNA complex. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Orthologous to human RBPJ (recombination signal binding protein for immunoglobulin kappa J region). [provided by Alliance of Genome Resources, Apr 2022]

Rbpj Products (1)

mRNA Protein Name
NM_001106631.2 NP_001100101.1 recombining binding protein suppressor of hairless

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
11997524 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
12145413 RGD
involved in negative regulation of smooth muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
15247148 RGD
involved in negative regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
15247148 RGD
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
9790494 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
15247148 RGD
Cellular Component GO Annotation Evidence References Source
part of protein-DNA complex IDA
IDA: Inferred from direct assay
10773077 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
11997524 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

recombining binding protein suppressor of hairless

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-137471 RBPJ Inhibitor-1 Inhibitor 99.87% Unkown
HY-116940 Sm4 Inhibitor 99.01% Unkown
HY-RS11772 RBPJ Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17271 Rbpj Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23725 Rbpj Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rbpj NCBI NCBI:3516