TCF7L2 - Tcf7l2 transcription factor 7 like 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 679869

Summary

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; armadillo repeat domain binding activity; and beta-catenin binding activity. Involved in negative regulation of apoptotic process and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be part of beta-catenin-TCF7L2 complex and protein-DNA complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate Cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2). [provided by Alliance of Genome Resources, Apr 2022]

TCF7L2 Products (1)

mRNA Protein Name
NM_001191052.2 NP_001177981.1 transcription factor 7-like 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
21901280 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
21965303 RGD
involved in negative regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
21901280 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21901280 RGD
involved in negative regulation of type B pancreatic cell apoptotic process IMP
IMP: Inferred from mutant phenotype
21965303 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21965303 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor 7-like 2

  • transcription factor 7-like 2 (T-cell specific, HMG-box)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W010995 2,5-Dimethylcelecoxib Inhibitor 99.57% Unkown
HY-N3628 Coronarin A Inhibitor ≥98.0% Unkown
HY-RS14310 TCF7L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17858 Tcf7l2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24327 Tcf7l2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens TCF7L2 NCBI NCBI:6934