Grhpr - glyoxylate and hydroxypyruvate reductase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 680021

Summary

Enables carboxylic acid binding activity; nucleotide binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in dicarboxylic acid metabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase). [provided by Alliance of Genome Resources, Apr 2022]

Grhpr Products (1)

mRNA Protein Name
NM_001113754.1 NP_001107226.1 glyoxylate reductase/hydroxypyruvate reductase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables NAD binding IDA
IDA: Inferred from direct assay
2689175 RGD
enables NADP binding IDA
IDA: Inferred from direct assay
2689175 RGD
enables carboxylic acid binding IPI
IPI: Inferred from physical interaction
2689175 RGD
enables glyoxylate reductase (NADPH) activity IDA
IDA: Inferred from direct assay
2689175 RGD
enables hydroxypyruvate reductase (NADH) activity IDA
IDA: Inferred from direct assay
2689175 RGD
enables hydroxypyruvate reductase [NAD(P)H] activity IDA
IDA: Inferred from direct assay
2689175 RGD
Biological Process GO Annotation Evidence References Source
involved in dicarboxylic acid metabolic process IDA
IDA: Inferred from direct assay
2689175 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glyoxylate reductase/hydroxypyruvate reductase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-142035 N-Propargylglycine 99.70% Unkown
HY-RS05790 GRHPR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18067 Grhpr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24542 Grhpr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grhpr NCBI NCBI:9380