Rnf146 - ring finger protein 146 Gene

Predicted to enable poly-ADP-D-ribose binding activity and ubiquitin-protein transferase activity. Predicted to be involved in several processes, including negative regulation of hydrogen peroxide-induced cell death; positive regulation of canonical Wnt signaling pathway; and protein ubiquitination. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in genitourinary system. Used to study cleidocranial dysplasia. Orthologous to human RNF146 (ring finger protein 146). [provided by Alliance of Genome Resources, Apr 2022]